Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have developed antibodies that have two antigen-binding sites and can couple cancer cells with effector cells of the immune system. In laboratory tests, these bridging antibodies, together with an enhancer antibody, were able to specifically mobilize the body's own immune defenses and destroy breast cancer cells.

Scientists use super-resolution microscopy to study previously undiscovered cellular worlds, revealing nanometer-scale details inside cells. This method revolutionized light microscopy and earned its inventors the 2014 Nobel Prize in Chemistry. In an international collaboration, AI researchers from Tübingen have now developed an algorithm that significantly accelerates this technology.

Christiane Opitz, scientist at the German Cancer Research Center, is being awarded this year's Ita Askonas Prize of the European Federation of Immunological Societies. Opitz has discovered how tumor cells use certain metabolites to protect themselves against the immune system. Her research findings may provide important clues for the development of new therapeutic concepts.

On the one hand, blood vessels supply tumors with nutrients and, on the other, enable cancer cells to spread throughout the body. The settlement of circulating tumor cells in a distant organ is promoted by factors whose production is induced by the primary tumor itself. Scientists have now identified a new growth factor produced by blood vessels that enables tumor cells to metastatically colonize organs.

As a rapidly growing renewable raw material, bamboo is an ideal substitute for wood. However, bamboo’s susceptibility to mold in damp conditions poses a problem. Researchers at Fraunhofer have now analyzed bamboo’s response to moisture under specific climatic conditions. By using simulation software, building owners can plan and implement measures to prevent the growth of mold.

Reduction of greenhouse gases in wine production - 31/08/2021

The REDWine project and climate change

In the EU project REDWine, the CO2 produced during wine fermentation is captured and used to produce algae biomass. Novis GmbH from Tübingen supplies the complete system for CO2 utilisation. The aim of the project is to reduce the share of global warming caused by wine production in a way that is economical for producers.

Expert interview - 31/08/2021

Health Data Scenarios - many possibilities for the future?

The digitization of healthcare is progressing slowly but steadily. In addition to simple telemedical applications, data such as electronic patient records are forming the basis of digitization. The ‘Health Data Scenarios’ project aims to model the future of healthcare data by using scenarios. Lucas Scherdel, Healthcare Innovation Director at DayOne, and Dr. Alexander Fink, founder and CEO of ScMI AG, explain how this will work.

CureVac N.V. (Nasdaq: CVAC), a global biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (“mRNA”), today announced the publication entitled “Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model” in the peer-reviewed Journal of Hepatology.

In August 2021, the BioMat Pavilion 2021 was inaugurated on the campus of the University of Stuttgart in a ceremonial setting and in compliance with the hygiene concept. The core of the elegantly curved lightweight construction is an active-bending structure made of natural fibers, reminiscent of bamboo. It was developed as part of the "LeichtPRO" research project.

An international research team has calculated the potential for material efficiency strategies in residential buildings and passenger cars. Up to two-thirds of global emissions could be saved in these areas, provided that appropriate strategies are consistently implemented.

New drugs are intended to help stop viral zoonoses – infections that jump from animals to humans. To study suitable inhibitors, Prof. Dr Christian Klein from the Institute of Pharmacy and Molecular Biotechnology (IPMB) of Heidelberg University is receiving funding in the amount of 450,000 euros from the Volkswagen Foundation.

3R-Center - 18/08/2021

Putting alternatives to animal testing into practice

Animal experiments are still central to biomedical research. However, it has become increasingly clear that not all of them are absolutely necessary. Alternative techniques exist. The new 3R-Netzwerk Baden-Württemberg is now seeking to promote these more vigorously - and improve animal welfare in cases where alternatives to animal testing are not available.

The risk of colorectal cancer can be predicted more accurately by determining seven blood-based micro-RNAs (miRNAs) than by using traditional methods - and can be done so many years before a diagnosis is made. In a current study, researchers from the German Cancer Research Center and the National Center for Tumor Diseases (NCT) Heidelberg show that miRNA profiles provide greater predictive accuracy than genetic or lifestyle-based risk…

As a dominant part of southern Germany’s life-science industry hub, Heidelberg will soon have a life-science startup incubator of its own. BioLabs, the premier US network of managed co-working lab space, will open its first German branch in the Heidelberg Innovation Park (hip). On August 16, representatives of city and state governments, BioLabs and the life-science industry celebrated the Heidelberg BioLabs groundbreaking.

Plastics from the field - 12/08/2021

Great potential for biological residues

Huge amounts of waste are produced both during food production and by consumers. The Conversion Technologies of Biobased Resources group at the University of Hohenheim’s Institute of Agricultural Engineering has developed a process to convert this biomass into hydroxymethylfurfural (HMF), the highly potent basic chemical that is used to produce plastics.

Workplace of the future - 10/08/2021

Intelligent body support system for surgery staff

Operating room staff often spend hours in strenuous postures, which has a significant impact on concentration and quality of work. While operating room equipment is increasingly networked, state-of-the-art medical technology, conditions for operating room staff trail way behind. The start-up company Hellstern medical offers an effective solution for serious pain, fatigue and incorrect interventions.

Digitalisation - 04/08/2021

Eye check for all - quick and easy thanks to artificial intelligence

Many eye diseases are already easily treatable, if they are detected in time. But waiting months for an ophthalmologist’s appointment seems to be the norm - that is, if you can get to see a specialist at all. The Tübingen-based start-up eye2you wants to improve this situation: it has developed a mobile retinal examination device involving a smartphone and AI. It can be used by family doctors, diabetologists and nursing staff and thus help to…

ROKO Farming - 03/08/2021

Thinking upwards: vertical farming to be further developed into continuous production

ROKO Farming’s novel technology is designed to produce fruit and vegetables worldwide all year round, while also freeing up areas for rewilding. This semi-automatic production method created by the Ulm-based business has huge future potential, as their success in innovation competitions demonstrates.

Carbon dioxide is one of the main drivers of climate change – which means that we need to reduce CO2 emissions in the future. Fraunhofer researchers are highlighting a possible way to lower these emissions: They use the greenhouse gas as a raw material, for instance to produce plastics. To do this, they first produce methanol and formic acid from CO2, which they convert via microorganisms into building blocks for polymers and the like.

The Hallertau is Germany's largest hop-growing region. During harvesting, hop bine chaff is left over, which is converted into environmentally friendly bio natural gas on site in a biogas plant. But that is not the end of the utilization chain for this fiber plant. Researchers at the German Institutes of Textile and Fiber Research Denkendorf (DITF) have used the plant-containing biogas digestate to produce a composite material that can be…

Alpha-Protein GmbH - 27/07/2021

Insect farming for sustainability

Mealworms instead of fish meal and soybean meal - this is what the sustainable future of feed production looks like as Alpha-Protein GmbH see it. The company has built a highly efficient automated production plant in which residual materials from local food production are used to breed mealworms.

PixelBiotech GmbH - 27/07/2021

Searching for tracks with cytogenetics and AI

The startup Pixelbiotech combines fluorescence techniques with artificial intelligence to detect DNA and RNA in medical samples. HuluFISH is the name of the method, which allows for countless applications - from detecting viral infections, such as COVID-19 or African swine fever virus, to the quality control of gene and immunotherapeutic procedures in cancer medicine.

Scientists from the German Cancer Research Center and Heidelberg University Hospital have for the first time been able to delay the development of hereditary colorectal cancer with a protective vaccination. Mice with a hereditary predisposition to colorectal cancer survived significantly longer after vaccination than unvaccinated animals. Combining the vaccination with an anti-inflammatory drug increased the protective effect.

Gene regulation - 20/07/2021

The many faces of the epigenetic regulator MOF

Epigenetic modifications play a crucial role in coordinated gene transcription, and are required for a fertilised egg cell to be able to develop into an organism with different cell types. Dr. Asifa Akhtar from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg has been studying the essential epigenetic regulator protein MOF for 20 years.

The "livMatS Pavilion" in the Botanical Garden of the University of Freiburg is a model for a bioinspired sustainable construction. In a joint project, researchers from the Universities of Freiburg and Stuttgart together with master’s students from the University of Stuttgart have designed a lightweight pavilion.

To diagnose an infection with the coronavirus, usually a throat swab is taken and genetic viral material detected by using a highly sensitive PCR. To date, more than 65 million of these tests have been performed in Germany alone. Due to the massive increase in testing worldwide and simultaneous loss of production, there was a significant shortage of test materials in the early stage of the pandemic.

Under certain conditions, our immune system can efficiently fight off infectious diseases and cancer. T cells, especially the gamma delta T cell type, play an important role in this. The issue is that this cell type is extremely infrequent in the human body. Researchers at the University Hospital Tübingen, the University of Heidelberg and the European Molecular Biology Laboratory (EMBL) have now succeeded in finding the cause for the formation of…

Age-related macular degeneration (AMD) is the commonest cause of blindness in developed countries affecting seven million in total in Germany, from which 500,000 people are suffering from late stage disease, around half of whom are registered as visually impaired. There are two forms of AMD, ‘wet’ and ‘dry’. There are currently no treatments available for the dry form of the disease (geographic atrophy).

Through a complex, self-reinforcing feedback mechanism, colorectal cancer cells make room for their own expansion by driving surrounding healthy intestinal cells to death - while simultaneously fueling their own growth. This feedback loop is driven by an activator of the innate immune system. Researchers from the German Cancer Research Center (DKFZ) and the University of Heidelberg discovered this mechanism in the intestinal tissue of fruit…

Refuels are renewable fuels that can be produced in different ways. When they are mixed and processed such that they meet the existing fuel standards, they are suited for all types of combustion engines. This is the result of the latest vehicle and fleet tests within the project “reFuels – Rethinking Fuels” at Karlsruhe Institute of Technology (KIT). Compared to fully fossil fuels, refuel mixes allow for a CO2 reduction by 25% at least. Moreover,…

Article - 08/07/2021

Individual operation risk assessment by the Cognitive Medical Assistant

Despite modern surgical techniques and anaesthetic procedures, serious complications can occur during surgical interventions. An interdisciplinary team at Heidelberg University Hospital has launched a project called the Cognitive Medical Assistant (German: Der Kognitive Medizinische Assistant, KoMed for short), designed to better assess the individual risk of these interventions. The project’s goal is to systematically and comprehensively analyse…

The European Union is largely dependent on imports of white phosphorus (P4), a strategic raw material for the food and pharmaceutical industries. To tackle this challenge, the newly started four-year EU-funded project FlashPhos – led by the University of Stuttgart – will recover at a large scale high-quality white phosphorus and other raw materials using sewage sludge as input material.

Scientists from the EMBL and the German Cancer Research Center have presented a new method for generating metabolic profiles of individual cells. The method, which combines fluorescence microscopy and a specific form of mass spectroscopy, can analyze over a hundred metabolites and lipids from more than a thousand individual cells per hour. Researchers expect the method to better answer a variety of biomedical questions in the future.

Start-up kernique catch the zeitgeist - 29/06/2021

Nut snack as a sustainable ecological concept

A delicious vegan nut snack that uses no sugar, artificial additives, gluten or palm oil, is full of essential nutrients, and is part of a commitment to environmental and social sustainability. Impossible? An Esslingen-based start-up called kernique proves otherwise. The start-up is currently planning a crowdfunding phase that offers a lucrative deal for investors. The idea catches the zeitgeist, but what exactly makes it stand out?

For the first time, scientists from the German Cancer Consortium (DKTK) partner site in Essen/Düsseldorf have discovered stem cells of the hematopoietic system in glioblastomas, the most aggressive form of brain tumor. These hematopoietic stem cells promote division of the cancer cells and at the same time suppress the immune response against the tumor.

Article - 22/06/2021

Using virtual reality in the clinic to rehabilitate patients with cognitive disorders

Outdated and inadequate methods of neurological rehabilitation are still being used for patients with neurological diseases or injuries – and what’s more, the treatment is usually too late. This is because cognitive training is especially important in the critical phases when the brain is particularly plastic. The Heidelberg-based company living brain proves that early treatment is possible using an extremely innovative method – with concentrated…

The EU funded research project HyFlexFuel recently succeeded to produce biocrudes via hydrothermal liquefaction (HTL) from a variety of biomasses, including sewage sludge, food waste, manure, wheat straw, corn stover, pine sawdust, miscanthus and microalgae in a pilot-scale continuous HTL plant at Aarhus University (Denmark).

Which neurons in the brain mediate fear responses - and how do they flip the switch when the danger is over? The research team of Prof. Ingrid Ehrlich at the Institute of Biomaterials and Biomolecular Systems (IBBS), Department of Neurobiology studies these questions. Their latest results obtained in collaboration with scientists at the Friedrich Miescher Institute in Basel (Switzerland), the National Institute of Health (USA), and Innsbruck…

CureVac N.V. (Nasdaq: CVAC), a clinical-stage biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (“mRNA”), today announced results of the second interim analysis of its international pivotal Phase 2b/3 study in approximatively 40,000 subjects (the HERALD study) of CureVac’s first-generation COVID-19 vaccine candidate, CVnCoV.

It is not the first time that spiders have served as biological models in the research field of soft robotics. The hydraulic actuation mechanisms they apply to move their limbs when weaving their web or hunting for prey give them powers many roboticists and engineers have drawn inspiration from.

Microorganisms are the oldest, most abundant, and most diverse life forms on earth and offer enormous potential for biotechnological applications. To date, however, only a fraction of them could be isolated and cultivated. The “MicroMATRIX” research project, funded with € 1.5 million by the German Federal Ministry of Education and Research and led by Karlsruhe Institute of Technology (KIT), aims to shed more light on the microbial darkness.

Effective drugs for the treatment of diseases of the central nervous system do exist. However, the blood-brain barrier, which protects the brain as the body's control center, makes it especially difficult for therapeutic biomolecules to pass through. Thus, researchers from an international consortium coordinated by the Fraunhofer IGB have spent the last four and a half years developing a novel system in the EU project "N2B-patch"…

Article - 10/06/2021

New study: vaccine therapy for treating patients with chronic leukaemia

Personalised peptide vaccination is expected to improve the treatment of patients with chronic lymphocytic leukaemia. A research team from Tübingen has started a Phase I clinical trial with CLL patients who will undergo ibrutinib treatment. Other leukaemia sufferers as well as cancer patients in general are also expected to benefit in the long term.

The final report including comprehensive fact sheets of 25 applications is now available online in German and English.

Final chord of the EU-project Smart SMEs - 31/05/2021

Building a sustainable network for natural fibre-based SMEs in the Alpine Space

The European project Smart SMEs came successfully to its end in May 2021 with the final conference, which attracted participants from different parts of Europe.

Final chord of the EU-project Smart SMEs - 31/05/2021

Building a sustainable network for natural fibre-based SMEs in the Alpine Space

The European project Smart SMEs came successfully to its end in May 2021 with the final conference, which attracted participants from different parts of Europe.

Zero Bullshit Company - 31/05/2021

From being thrown away to becoming a recycled product - Stuttgart start-up produces healthy snacks

Throwing away food? The Stuttgart-based start-up Zero Bullshit Company is declaring war on food wastage by making nutrient-rich products largely from food industry leftovers. The three food technologists who created this transparent brand are looking to develop more than just delicious and nutritious products.

Article - 31/05/2021

Tracking down tumour-associated pain in pancreatic cancer

Pancreatic cancer comes along quietly: unnoticed for a long time, it often triggers excruciating pain as the tumour progresses. This pain is associated with cancer cells invading pancreatic nerves. Dr. Michael Hirth from Mannheim University Hospital has shed some light on the complex communication between cancer cells and nerve cells. His findings could eventually be used for personalised pain therapies.

Installing the next digital generation of computed tomography at various Baden-Württemberg medical centres (PC3)

The pulp of coffee beans is considered a waste product on coffee plantations, which is usually thrown away or dumped into rivers - with significant negative consequences for climate change and the environment. Macarena San Martín-Ruiz from the University of Stuttgart is working with Coopetarrazú, the largest coffee cooperative in Costa Rica, to find out how the mixture of pulp and husks can be turned into organic compost and thus protect the…

The Deep-Tech Start-Up memetis GmbH from Germany, which produces the world’s most compact and lightest commercially available valves driven by shape memory alloys, announces a new partnership with Fluid-o-Tech S.r.l., an Italian innovation and market leader in the field of fluid-pumps.

The bacterium Staphylococcus epidermidisis primarily a harmless microbe found on the skin and in the noses of humans. Yet some strains of this species can cause infections – in catheters, artificial joints, heart valves, and in the bloodstream – which are difficult to treat. These bacteria are often resistant to a particularly effective antibiotic, methicillin, and are among the most feared germs in hospitals.

Brain tumor cells with a certain common mutation reprogram invading immune cells. This leads to the paralysis of the body's immune defense against the tumor in the brain. Researchers from Heidelberg, Mannheim, and Freiburg discovered this mechanism and at the same time identified a way of reactivating the paralyzed immune system to fight the tumor.

Vaccine development - 25/05/2021

Vaccines - a beacon of hope in the fight against pandemics

Having long been considered less lucrative for the big pharmaceutical companies, vaccine development is taking off in an unforeseen way in the wake of the COVID-19 pandemic. Financial support is flooding in and all kinds of vaccine development strategies are being deployed. Among the winners in the competition for effective coronavirus vaccines are vaccines based on RNA technology.

Data generated by the healthcare system has enormous potential for improving the quality of patient-centered care. As part of the Health Data Scenarios project, Basel Area Business & Innovation worked with numerous experts from industry and academia in 2020 to develop ten scenarios of what future health data ecosystems could look like. These scenarios are now being discussed and validated together with experts and opinion leaders from…

The Bio-based Industries Joint Undertaking (BBI JU) has signed the grant agreements with 18 new projects, selected for funding under the 2020 Call for proposals. 199 beneficiaries from 26 countries across the EU and beyond will receive BBI JU’s financial support worth €104.5 million. This is the seventh and last BBI JU call which will bring the total investment of the initiative to €821.6 million and the BBI JU’s portfolio to 142 projects.

Signal mechanisms in inflammatory processes - 18/05/2021

Newly discovered substances activate the inflammasome in macrophages

Low-grade chronic inflammation caused by components of the innate immune system may increase the risk of developing a variety of diseases in the long term. In their search for the signalling mechanisms underlying these inflammatory processes, Prof. Dr. Olaf Groß' research group at the Freiburg University Medical Centre discovered new active substances with immunostimulatory properties that may open up additional possibilities in cancer…

The working group around Dr. Philipp Rathert at the Institute for Biochemistry and Technical Biochemistry investigates the regulation of epigenetic networks of certain cancers and ways of treating them. The working group published its new findings in April.

The amount of plastic waste increases every year. Some of this waste is due to plastic packaging used to protect food. As part of the “BioActiveMaterials” project, researchers at the Fraunhofer-Gesellschaft have developed an eco-friendly coating for paper packaging. With this, not only is plastic saved, but the coating of plant-based proteins and waxes also extends the shelf life of the food.

Freiburg researchers have studied how changing their diet could influence the ecological footprint of Germans.

Article - 29/04/2021

Nanobodies for determining neutralising antibodies after corona infection

After contact with a pathogen, ideally our immune system generates neutralising antibodies to prevent a future infection. With NeutrobodyPlex, scientists from Reutlingen and Tübingen have developed a highly specific test procedure based on single-domain antibodies (nanobodies) that can be used to easily and reliably determine the quality of the immune response against the novel coronavirus.

Population growth and the increasing standard of living make our society face big ecological challenges: Climate change, littering of the seas, dwindling agricultural areas, resource scarcity. Bioeconomy aims at replacing fossil by regenerative resources and at using advanced and sustainable technologies based on biological knowledge and principles.

The BioSinn project found products and applications for which biodegradation at the end-of-life is a real option. 25 fact sheets answer technical and regulatory questions for each application. The market volume of these applications was also estimated: in Germany it is about 170,000 tonnes, in the European Union about 1 million tonnes per year!

The study “Life and Biological Sciences and Technologies as Engines for Bio-based Innovation”, funded by the European Commission, DG Research and Innovation has been published and is now available for download from the website of the Publications Office of the European Union.

Atriva Therapeutics GmbH, a company that is pioneering the development of therapies for the treatment of viral infections, has secured up to €11.4 million in federal funding. The company, founded in 2015, announced today that it was selected for research funding from the German Federal Ministry of Education and Research (BMBF). Atriva will use the funds to advance its drug ATR-002 towards market maturity as quickly as possible.

Protecting the global climate is an undertaking that presents both industry and society with a major task. It will not be possible to achieve the climate targets simply by limiting global emissions, by saving carbon dioxide (CO2). This is because there will continue to be unavoidable CO2 emissions that will nevertheless have to be compensated.

Genetically enhancing a patient's immune cells by adding therapeutic genes to them outside the body is regarded as a promising new treatment approach in oncology. However, the production of these therapeutic cells using viruses is not only expensive but time-consuming. Researchers at the German Cancer Research Center (DKFZ) have developed an innovative non-viral vector that can efficiently introduce therapeutic genes into immune cells.

Article - 14/04/2021

Calling for quality seal for implants

Today's seniors are older and more active, which is why implants remain in the body longer and are subjected to greater strain than before. Improved surfaces are expected to ensure that the implants heal and integrate into the bone optimally. In an interview with BIOPRO, Dietmar Schaffarczyk, CEO of Konstanz-based stimOS GmbH, explains why a voluntary quality seal makes sense and gives consumers a better chance of recognising high-quality…