CRISPR/Cas9 and genetic engineering laws - 27/11/2019

Transgene-free plant breeding using genome editing

Plant geneticists from Tübingen have used genome deletion to breed a variety of tomato that is resistant to powdery mildew. The CRISPR/Cas9 technology that they used enabled them to achieve this in a relatively short period of time. They also demonstrated beyond any doubt that the new tomato variety contains no foreign DNA and is indistinguishable from naturally occurring deletion mutants.

Article - 18/11/2019

Researchers successfully rejuvenate the immune system in animal models

It is well known that stem cells age. Even the human immune system loses its power with age. Since all immune cells are derived from blood-forming stem cells, it is quite natural to associate the weakening of the immune system (immune senescence) with the ageing of blood-forming stem cells. Stem cell researchers and immunologists from the University of Ulm have now demonstrated the important role that blood-forming cells play in the ageing of the…

Dossier - 15/11/2019

Microplastics waste is a valuable resource – it is just in the wrong place

The negative image of plastic persists and is not getting any better in the face of the ongoing debate about microplastics which are basically everywhere. Plastic pollutes the environment. The globe is littered with huge quantities. We have to modify the production and utilisation of macroplastics as well as fundamentally rethink the way we dispose of them. ‘Out of sight, out of mind’ mentality must become a thing of the past.

Article - 08/11/2019

Nanorobots as future minimally invasive tools for the eye

It is difficult to place drugs in the right place in the eye. When using droplets, only a small fraction of the drug reaches its target. Injecting drugs into the eye is also more a matter of luck than judgement. Basic researchers at the Max Planck Institute for Intelligent Systems Stuttgart have developed a nanorobot that can be loaded with active ingredients for treating eye diseases and directed through the solid tissue of the vitreous body.

Article - 30/10/2019

Fuel from CO2 – compact decentralised facilities enable emission-free mobility

Can greenhouse gases like CO2 and methane be used to fuel cars? What sounds like wishful thinking is in fact already reality at INERATEC. The company’s compact mobile systems equipped with a unique chemical reactor technology are attracting worldwide interest. The systems enable CO2-free mobility for road traffic, aviation and shipping. Is this development close to successful market entry?

Article - 22/10/2019

Using CAR T cells for treating cancer

After successes in the treatment of advanced blood cancers, CAR T-cell immunotherapy has become a major beacon of hope in oncology. The first therapies have received regulatory approval. Despite their success, these immunotherapies can have serious side effects. The company AVA Lifescience develops antibodies with high tumour specificity to use as the basis for effective precision-guided CAR T-cell therapies that are better tolerated by patients.

Article - 21/10/2019

Plant pots made of natural fibres – "bio", no ifs or buts

Plastic plant pots are not good for the environment; strictly speaking, they should not even be disposed of in recycling bins. Alternatives such as coconut fibre pots are compostable, but not pollutant-free and not "bio" at all. The Karlsruhe-based company Fiber Engineering has developed a truly ecofriendly way to grow plants: pots made of hemp or grass, which are preserved with biological components and decompose completely within a…

Article - 15/10/2019

docdirekt – a smart way to contact a doctor in Baden-Württemberg

You feel unwell, but the family doctor’s practice is closed or it’s impossible to get an appointment at short notice. As part of their docdirekt project, the Baden-Württemberg Association of Statutory Health Insurance Physicians (in German: "Kassenärztliche Bundesvereinigung Baden-Württemberg (KVBW)) is now offering help for such cases. Everyone signed up to the statutory health insurance scheme will now be able to ring, contact via apps or…

Article - 09/10/2019

Epigenomics from the Cyber Valley

Cyber Valley Stuttgart-Tübingen is a European hotspot for artificial intelligence and home to many renowned experts and scientists. They are now joined by Gabriele Schweikert, who heads up the Computational Epigenomics research group in the Cyber Valley’s Division of Computational Biology. Schweikert is interested in exploring epigenetic mechanisms using machine learning methods.

Article - 30/09/2019

Do gut bacteria have something to do with autism?

Autistic people have different gut microorganisms than non-autistic people. Researchers believe that a disturbed intestinal flora may play a role in developmental disorders of the brain such as autism. The emerging new field of metaproteomics could shed light onto the matter. A team led by Prof. Dr. Boris Macek from Tübingen has investigated the bacterial protein pool in the faeces of mice that display autistic behaviour.

Expert interview on NTDs – part 3 - 24/09/2019

Neglected tropical diseases – Franz-Werner Haas: the role of technology and pharmaceutical companies

Neglected tropical diseases (NTDs) are poverty-related infectious diseases that suffer from scant attention in terms of research or control. NTDs exist in the shadow of the "big three": malaria, tuberculosis and HIV/AIDS. They affect many people living in poverty in the emerging and developing countries of the tropics and subtropics. Active control can only be achieved when people with NTDs are treated effectively and given information…

Article - 19/09/2019

Magnetised algae as microrobots for medical and environmental purposes

Algae, for most of us, is something that lives in water courses that we occasionally find unpleasant. However, that is to do them a wrong. These extremely versatile and frugal organisms might in future prove to be extremely important. Scientists at the University of Stuttgart are investigating how algae can be used as microrobots in biomedicine and environmental remediation.

Article - 19/09/2019

Magnetised algae as microrobots for medical and environmental purposes

Algae, for most of us, is something that lives in water courses that we occasionally find unpleasant. However, that is to do them a wrong. These extremely versatile and frugal organisms might in future prove to be extremely important. Scientists at the University of Stuttgart are investigating how algae can be used as microrobots in biomedicine and environmental remediation.

Dossier - 09/09/2019

Artificial intelligence in medicine: assistance for human senses

There is no way around it. Whether we like it or not, artificial intelligence (AI) has long been part of our lives, in traffic management, marketing campaigns or in the fields of medicine and life sciences. AI is omnipresent, often without us being aware of it. Baden-Württemberg is home to one of the largest AI research consortia in Europe and has recently become one of the European hotspots for this key technology.

Vision Zero in oncology - 02/09/2019

Call for a comprehensive master plan for preventing and treating cancer

While a cancer-free world may seem unrealistic given the increasing numbers of cancer cases, we need to reach a social consensus that cancer deaths are unacceptable and that everything possible must be done to prevent them. Leading cancer researchers around the world are calling for more investment in prevention research and cancer screening to move towards the vision of a near cancer-free world.

Two-part interview part 2 | Prof. Dr. Ortwin Renn on the green genetic engineering debate - 26/08/2019

"Green genetic engineering is a scapegoat, but no longer an innocent one"

Many scientists are expecting revolutionary advances in research to come from new molecular biology tools such as the CRISPR/Cas gene scissors. These methods are very important for agriculture, especially plant breeding and nutrition. However, the debate on green genetic engineering 2.0 looks like it may once again be heading for ideological battles. We talked with Prof. Dr. Ortwin Renn and asked him about opportunities for better communication.

Two-part interview part 1 | Prof. Dr. Regina Birner on the green genetic engineering debate - 12/08/2019

Agricultural economist Birner calls for other forms of dialogue besides organized interest groups

Green genetic engineering continues to divide opinion in Germany in the same way as CRISPR/Cas and other genome editing (GE) techniques. What are the consequences for the bioeconomy, which involves key areas of biotechnology? We talked with Prof. Dr. Regina Birner, agricultural economist and head of Hohenheim University’s Department of Social and Institutional Change in Agricultural Development at the Institute of Agricultural and Social…

Article - 01/08/2019

Clean water thanks to microplastics

He swam the entire length of the River Rhine to draw attention to the contamination of rivers and oceans with plastic waste. After completing his mammoth swim, Prof. Dr. Andreas Fath decided to kill two birds with one stone and do something useful with microplastics. At the Furtwangen University of Applied Sciences campus in Villingen-Schwenningen, Fath is working on a filter system made of plastic waste that can be used to remove pollutants from…

Article - 26/07/2019

New test assay leads to discovery of new influenza virus infection route

Researchers from the University of Freiburg have recently discovered a completely new mechanism that influenza viruses use to infect cells. This discovery was partly made possible by a so-called emulsion coupling assay - an extremely sensitive, digital detection method developed by Actome GmbH in collaboration with scientists from the Freiburg University of Applied Sciences and Hahn-Schickard. The assay is used to count individual molecules and…

Article - 10/07/2019

More than just a nut – new products for the bioeconomy

Plants are often used for one particular purpose only. However, walnut trees have much more to offer than just delicious nuts. The AlpBioEco project is studying the potential of walnut trees for the bioeconomy and how the potential can be exploited commercially. The international team of researchers is also focusing on apples and herbs.

Article - 01/07/2019

Microswimmers for guided drug delivery

Medicines should act as quickly as possible and ideally only at the site of disease. However, this may be difficult when the medicines are taken up via the digestive tract or the blood system. Researchers at the Max Planck Institute for Intelligent Systems in Stuttgart have now developed a biohybrid microrobot consisting of red blood cells and bacteria that can be loaded with active ingredients.

Article - 11/06/2019

New pathogens in beef and cow's milk contributing to the risk of cancer

A team of researchers led by Nobel laureate Prof. Dr. med. Dr. h.c. mult. Harald zur Hausen has discovered a new type of infectious agent in dairy and meat products produced from European cattle that increases the risk for colon and breast cancer. These so-called Bovine Meat and Milk Factors (BMMFs) are small DNA molecules that are similar in sequence to both bacterial plasmids and certain viruses.

Expert interview on NTDs – part 2 - 29/05/2019

Neglected tropical diseases - Gisela Schneider: the burden of disease

"Leaving no one behind". The motto of the 2030 Agenda with its 17 Sustainable Development Goals (SDGs) which was signed by the United Nations (UN) in 2015 makes clear that combatting poverty and its consequences is an essential part of sustainable development. The fight against neglected tropical diseases (NTDs) is defined as a major aim of the Agenda’s sustainable development goals. The World Health Organisation (WHO) regards twenty…

Article - 27/05/2019

Providing Growledge - resources and products for the bioeconomy

Miscanthus and hemp are biomass plants that can be used as raw materials for a wide range of products and can be grown on land areas that are currently underutilised. A European consortium led by the University of Hohenheim in Baden-Württemberg has started a five-year project to demonstrate the economic potential of these plants.

New edition - 24/05/2019

Tumour metastasis

Cancer is usually not curable when metastases have formed in the body. Metastases are often resistant to drugs that have successfully eliminated the primary tumour. The basic features of the complex process of metastasis are now known, but many details still remain elusive. Intensive research activities are focusing on new therapeutic concepts aimed at developing effective anti-metastatic therapies.

Expert interview - 13/05/2019

Innovation management in the life sciences – Inova DE provides insights

Personalized medicine, medical technology, digital health and artificial intelligence are revolutionizing diagnostics and product development. Analyses are becoming faster and more precise, and data volumes can now be networked and used effectively. The goal of improving people's quality of life is within reach, and this will also strengthen Germany’s future viability. However, not every good idea can be turned into a marketable commodity.…

Article - 08/05/2019

Environmentally friendly alternative to fossil natural gas: methane from biomass

In cooperation with the research unit of the German Technical and Scientific Association for Gas and Water (DVGW), KIT researchers have built a pilot plant in which biogas produced by fermenting residual organic materials can be upgraded to synthetic methane (synthetic SNG). Biobased methane is not only a sustainable energy source for the heating and transport sectors, but also opens up new opportunities for temporary storage of renewable…

Article - 23/04/2019

How can care infrastructures benefit from digitization?

The pilot project NeCTra (Networking - Care - Transparency) investigates how care processes within an urban social environment can be improved by using digital technologies. The goal is to bring together all partners and institutions in real time so that people in need of care and those seeking advice receive appropriate support more quickly.

Article - 16/04/2019

Tumour monitoring using liquid biopsy

Liquid biopsy, the analysis of cancer biomarkers and circulating tumour cells in body fluids such as blood, is revolutionising the diagnosis and monitoring of cancer. It has also been possible to expand circulating tumour cells from the blood under laboratory conditions. It is expected that in the future, liquid biopsy will be able to precisely characterise tumour cells at every stage of a cancer.

Dossier - 15/04/2019

The alternative: “bioplastics”

Plastic waste takes years to decompose and pollutes the environment. Nevertheless, plastics are an indispensable part of everyday life. It is therefore all the more important to find a meaningful alternative that is sustainable, environmentally friendly and has better properties and more functionality than conventional plastics. In addition, such an alternative should not be dependent in any way on fossil resources.

Expert interview on NTDs – part 1 - 11/04/2019

Neglected tropical diseases – Carsten Köhler: impulses from Baden-Württemberg

More than one billion people worldwide suffer from neglected tropical diseases (NTDs). NTDs are mostly poverty-related infectious diseases that prevail in tropical countries due to lack of research and measures to detect, prevent and control them. Dr. Dr. Carsten Köhler reports on the political, economic and scientific contributions Germany and Baden-Württemberg can make to successfully change this situation.

Article - 03/04/2019

HKK Bionics empowers hand gripping functions

A spin-off from the Ulm University of Applied Sciences is aiming to provide people whose hands have been paralysed due to accident or illness with a new kind of orthopaedic aid. Dominik Hepp and Tobias Knobloch are currently starting serial production of a hand orthosis prototype. The two medical engineers from Ulm, who founded HKK Bionics GmbH in 2017, plan to commence final tests in 2019.

Article - 02/04/2019

Simple sugar could soon compete with glyphosate

For many decades, glyphosate has been a common component of agricultural pesticides worldwide, although it is a controversial herbicide that may be harmful. The good news is that a more sustainable alternative is now in sight: researchers from the University of Tübingen have discovered a sugar molecule called 7-deoxy-sedoheptulose (7dSh) which inhibits the growth of plants and microorganisms, but appears to be completely harmless to human cells.

Article - 28/03/2019

Supporting the human use of artificial intelligence

Artificial intelligence is no longer a vision of the future, but is already in our midst: whether it is parking aids or search engines, we use the technology quite naturally in many areas of daily life. It promises new, unlimited opportunities, but also poses risks. Experts from the Integrata Foundation in Tübingen work on ethical issues and the human use of IT for improving the life of as many people as possible.

Article - 27/03/2019

Residues from biogas plants as feed for algae

Algae are frugal organisms. They require only light, water, minerals and carbon dioxide to be able to produce biomass. These properties will now be exploited economically in a two-year research project. Dr. Stefan Sebök from the University of Hamburg plans to study the holistic utilisation of degradation products of a biogas plant in Wallerstädten by linking them to land-based algae cultivation.

Article - 22/03/2019

Personalised therapies for treating metastasing breast cancer

Breast cancer is characterised by broad genetic diversity. Successful treatment is made even more difficult by the fact that, in advanced breast cancer, the properties of metastases often differ significantly from the primary tumour. The Heidelberg CATCH study is now collecting genetic profiles from patients' metastasis tissue samples, which can be used to tailor therapy to individual requirements.

Article - 21/03/2019

Education as the key to a successful transition into a bioeconomy

National and international policy papers emphasize the role of the education sector in the transition into a bioeconomy. On the practical level, various actors are working on programmes to prepare professionals for future challenges. The University of Hohenheim, for example, offers a bioeconomy master's programme and is one of the universities that have laid the cornerstone for the “European Bioeconomy University” consortium.

Article - 18/03/2019

EHR and PHR: digital records in the German healthcare system

EHRs, i.e. electronic health records (German: Patientenakte, ePA), are hailed as the key to increasing the quality of care. The Appointment Service and Supply Act (TSVG), adopted on 14th March 2019, requires the German statutory health insurance funds to provide policyholders with electronic health records from 1st January 2021 onwards.

Article - 12/03/2019

Biocarbon fibres made of lignin

Carbon fibre is increasingly found in airplanes, cars and wind turbines. Carbon fibre is still made from oil and relatively expensive. However, this is soon to change. Researchers from the German Institutes of Textile and Fibre Research in Denkendorf (DITF) are working on the development of cost-effective carbon fibre made of lignin, a by-product of papermaking.

Article - 05/03/2019

Vaccination against oncogenic Epstein-Barr viruses

Almost all humans are infected with Epstein-Barr viruses (EBV), which are linked to the development of benign diseases such as infectious mononucleosis as well as several cancers. Scientists from the German Cancer Research Center have developed a new strategy for creating a vaccine that targets different EBV virus life phases and has the potential to provide effective protection against EBV infection.

Dossier - 04/03/2019

Sustainable textiles

Baden-Württemberg is known for innovation in textiles and for playing a decisive role in the development of sustainable textiles for the future both in the clothing and the booming technical textile sectors. Companies and research institutes are focused on making the entire textile value chain from raw materials, production and useful life to disposal more sustainable than ever before.