During the growth and development of living organisms, different types of cells must come into contact with each other in order to form tissues and organs together. A small team working with Prof. Dr. Anne Classen of the Excellence Cluster CIBSS of the University of Freiburg has discovered that complex changes in form, or morphogenesis, during development are driven exclusively via the affinity of cells to each other.

Toxicologists from the University of Konstanz have found that the protein p53 continuously protects our cells from tumorigenesis by coordinating important metabolic processes that stabilize their genomes.

Whether in drinking water, food or even in the air: plastic is a global problem - and the full extent of this pollution may go beyond of what we know yet. Researchers at the Karlsruhe Institute of Technology (KIT), together with partners from the Netherlands and Australia, have reviewed conventional assumptions for the transport of plastic in rivers.

The University of Stuttgart's MobiLab Real-World Laboratory aims to make Campus Vaihingen car- and emission-free. Research areas include autonomous vehicles and inductive charging while driving. In addition, MobiLab is helping to ensure that the University of Stuttgart will also be climate-neutral in the area of mobility and transport by 2030.

What will the energy systems of the future look like? What technical foundations do we need, and how can the upcoming transformation be shaped in such a way that we involve all actors in society? Answers to such questions are to be provided by four research projects funded by the Carl Zeiss Foundation (CZS) as part of the “CZS Breakthroughs – Energy Systems of the Future” program. One of these is based at the University of Stuttgart.

Viral cancer therapy - 26/10/2022

Therapeutic viruses against tumours and metastases

Viruses can overcome cell barriers and transfer information to their host cells. They know how to make their host cell’s infrastructure work for them. This makes them excellent biotechnological tools, which a research group from the Fraunhofer IGB in Stuttgart is using to its advantage. The team is developing a therapeutic virus that not only recognises and fights tumours, but also has the potential to reach metastases.

Heidelberg University scientists are to receive three ERC Synergy Grants – three highly endowed grants of the European Research Council – for pioneering research projects by several teams working in collaboration.

Why do metastases often only appear after the original tumor has been surgically removed? Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Mannheim Medical Faculty of Heidelberg University have now published an explanation for this phenomenon. They were able to identify a messenger substance of the cancer cells that locally promotes the growth of the primary tumor.

Remaining mobile and producing without overtaxing the earth’s natural regenerative capacity: That’s the aim of the Innovation Campus “Mobility of the Future” (ICM) at the Karlsruhe Institute of Technology (KIT) and the University of Stuttgart. Here, in about 60 research projects and 40 research institutes, almost 300 scientists are working on electric motors without rare earths, novel manufacturing technologies, and self-learning software systems…

Mobil bleiben und produzieren, ohne die natürliche Regenerationsfähigkeit der Erde zu überfordern, das ist der Anspruch des InnovationsCampus Mobilität der Zukunft (ICM) am Karlsruher Institut für Technologie und der Universität Stuttgart. Fast 300 Forschende in gut 60 Forschungsprojekten und 40 -instituten arbeiten hier an Elektromotoren ohne Seltene Erden, neuartigen Fertigungstechnologien und selbstlernenden Software-Systemen für Fahrzeuge.

The Carl Zeiss Foundation is funding the "DELIVER - Data-driven Engineering of Sustainable Living Materials" project at the University of Freiburg in its "CZS Wildcard" program. In the project, scientists from the Freiburg Clusters of Excellence CIBSS and livMatS will develop sustainable wood-based materials whose properties can be precisely controlled.

The Carl Zeiss Foundation is funding the "DELIVER - Data-driven Engineering of Sustainable Living Materials" project at the University of Freiburg in its "CZS Wildcard" program. In the project, scientists from the Freiburg Clusters of Excellence CIBSS and livMatS will develop sustainable wood-based materials whose properties can be precisely controlled.

Researchers of the University of Freiburg have discovered a previously unknown function of septins in defending cells against dangerous hospital pathogens.

University of Tübingen, a leading member of Cyber Valley, Europe’s largest Artificial Intelligence (AI) research consortium and Boehringer Ingelheim launch an AI and data science fellowship program for top talents from around the world. Three to five fellowships will be awarded per year for up to three years with a target of nine to fifteen fellows in the program after five years.

Apogenix, a biopharmaceutical company developing next generation immunotherapeutics, announced today that asunercept showed statistically significant benefits for hospitalized COVID-19 patients in the ASUNCTIS trial. The open-label multi-center phase II trial investigated efficacy and safety of asunercept in 435 patients with moderate to severe COVID-19 disease.

Researchers from Freiburg and Harvard publish the three-dimensional structure of the B cell antigen receptor, shedding new light on its composition.

Dossier - 19/10/2022

More food sustainability: crucial for people and for the environment

Strawberries in winter and imported apples? You can find them in most supermarkets. This is not sustainable. Looking to the future, the way we eat needs to change in many mundane ways – and this needs to happen quickly so that future generations will also be able to enjoy a planet that is worth living on. In Baden-Württemberg, alternative nutrition concepts are being worked at pace. Many creative ideas and innovative products already exist.

Dossier - 12/10/2022

The health sector must become greener

Worldwide, the health sector is struggling with the consequences of global warming, but fatally is itself responsible for a significant proportion of greenhouse gas emissions. Studies show that hospitals and rehabilitation clinics in particular have great potential for reducing these emissions and, like the manufacturing industry, need to fundamentally revise established processes.

Across the EU, more than 300 billion items of packaging are not recycled every year because they consist of a mixture of different materials. Monomaterial packaging on the other hand is easy to recycle. However, it needs to be coated with ultra-thin barrier layers to protect delicate products just as well as compound materials do.

Across the EU, more than 300 billion items of packaging are not recycled every year because they consist of a mixture of different materials. Monomaterial packaging on the other hand is easy to recycle. However, it needs to be coated with ultra-thin barrier layers to protect delicate products just as well as compound materials do.

More animal welfare and better animal health, more climate protection and less environmental impact: Researchers at the University of Hohenheim in Stuttgart are pursuing these goals with a new approach: They are exploring the interplay between farm animals and the millions of microorganisms in the animals’ digestive tracts. The federal and state governments are supporting the university with the construction of a unique research center for around…

Basic chemicals, which are needed as raw materials for a wide range of products such as medicines and detergents, can currently only be produced with an enormously high input of energy and raw materials. In many cases, fossil fuels and raw materials are still used. The extraction of chemical substances alone requires high temperatures, expensive catalysts made of precious metals and, in some cases, environmentally harmful starting materials.

Basic chemicals, which are needed as raw materials for a wide range of products such as medicines and detergents, can currently only be produced with an enormously high input of energy and raw materials. In many cases, fossil fuels and raw materials are still used. The extraction of chemical substances alone requires high temperatures, expensive catalysts made of precious metals and, in some cases, environmentally harmful starting materials.

In the brain of adult mammals neural stem cells ensure that new nerve cells, i.e. neurons, are constantly formed. This process, known as adult neurogenesis, helps mice maintain their sense of smell. A research team led by Dr Francesca Ciccolini at the Interdisciplinary Center for Neurosciences (IZN) of Heidelberg University recently discovered a second stem cell population in the mouse brain.

The glass facade of a high-rise building can get so hot that you can fry eggs on it – a major factor in the overheating of our cities. At the same time, flood events such as torrential monsoon rains cause billions of dollars of damage annually. On October 4, 2022, a solution to both problems was presented at the University of Stuttgart.

The glass facade of a high-rise building can get so hot that you can fry eggs on it – a major factor in the overheating of our cities. At the same time, flood events such as torrential monsoon rains cause billions of dollars of damage annually. On October 4, 2022, a solution to both problems was presented at the University of Stuttgart.

Büsnau biorefinery - 05/10/2022

KoalAplan: municipal wastewater as a source of recyclable materials

Our wastewater not only contains dirt and excretions, but is also rich in carbon, nitrogen and phosphorus, which can be recovered. A sewage plant can thus become a source of raw materials. In the KoalAplan project, a new type of biorefinery will be used to convert the carbon recovered from wastewater into sustainable products.

Although just cute little creatures at first glance, the microscopic geckos and octopuses fabricated by 3D laser printing in the molecular engineering labs at Heidelberg University could open up new opportunities in fields such as microrobotics or biomedicine. The printed microstructures are made from novel materials – known as smart polymers – whose size and mechanical properties can be tuned on demand and with high precision.

Fossil raw materials are limited and not available and extractable everywhere in the world – as we are becoming acutely aware of right now by the example of fossil fuels and rising energy prices. Renewable raw material sources will therefore play an increasingly important role in the future: as energy sources, but ideally also as suppliers of building blocks for more environmentally compatible chemicals and materials.

Screening trials for the early detection of rare diseases often fail due to insufficient predictive power of the results. For the rare HPV-related cancer of the pharynx, scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) now relied on the combined detection of antibodies against two different viral proteins in a proof-of concept trial.

Press release - 23/09/2022

Phytopharmaceuticals and valuable plant ingredients - opportunities for industry and agriculture in Baden-Württemberg

The "Phytopharmaceuticals and Valuable Plant Ingredients" initiative aims to make the key economic issue of phytopharmaceuticals more visible in Baden-Württemberg in order to gain a better understanding of the challenges and needs of the state’s pharmaceutical industry. The overall goal is to strengthen the use of secondary plant ingredients in valuable products and build on this to develop opportunities for Baden-Württemberg…

Hummingbird Diagnostics GmbH - 22/09/2022

The great potential of blood-based microRNA analyses

"The early bird catches the worm", is an apt description of what motivates Hummingbird Diagnostics GmbH from Heidelberg. The medium-sized biotechnology company analyses special biomarkers in blood, so-called microRNAs, in order to diagnose diseases at an early stage and to be able to make forecasts about the course of the disease and the success of therapy.

With its "Proof of Concept" grants, the European Research Council ERC supports scientists in further developing the commercial potential of their research results. Nina Papavasiliou from the DKFZ is now receiving the prestigious grant for the second time: she wants to advance the development of a "molecular delivery service" that ensures that therapeutic genes reach the right address in the body in a targeted manner.

Because of their highly active metabolism, many tumors are susceptible to a special type of cell death, ferroptosis. Nevertheless, cancer cells often manage to escape this fate. Scientists at the German Cancer Research Center have now discovered a new mechanism by which normal as well as cancer cells protect themselves against ferroptosis.

Article - 14/09/2022

Theranostics of prostate cancer: the combination of radionuclide diagnostics and radionuclide therapy

Using a low-level radiopharmaceutical that binds to the prostate-specific membrane antigen (PSMA), positron emission tomography/computed tomography can be used to visualise even small prostate cancer metastases. Developed by Heidelberg researchers, the radiopharmaceutical is a modified radionuclide diagnostic agent that has been coupled with a powerful emitter and used as a therapeutic tracer to irradiate and destroy cancer cells from within.

In its statement of September 2, 2022, the Bioeconomy Council of the German government condemns the Russian war of aggression on Ukraine and points out ways in which the resulting food and energy crisis can be alleviated with the help of the bioeconomy.

Cancer cells often grow in environments that are low in nutrients, and they cope with this challenge by switching their metabolism to using proteins as alternative "food". Building on genetic screens, an international team of scientists could identify the protein LYSET as part of a pathway that allows cancer cells to make this switch. Their findings are now published in the journal Science.

Dossier - 08/09/2022

Imaging methods in medical diagnostics

Many different imaging methods are available these days and are used in almost all medical disciplines to visualise disease-related changes. Depending on the problem and the clinical picture, very different structural and functional parameters can be visually recorded for diagnosis and used for therapy.

Today, genome editing is almost as easy as programming software. However, the generation of viral vectors as initial material is still associated with many expensive and error-prone handling procedures. Viruses are generated via complex biological processes that have to be optimised virus-specifically in order to produce high-quality therapeutics. A new method is needed that simplifies and optimises these processes.

Sustainable nutrition - 05/09/2022

Insect pasta: eating healthily and improving the world at the same time

Insects on the dinner plate? Some people instantly dismiss the idea. Wrongly so, because in terms of animal welfare, ecological footprint and healthy nutrition, insect foods are much better than all other animal foods and are produced in a more controlled way. The fact that they can also taste really good is proven by the start-up Beneto Foods from Albstadt, which has developed protein-rich pasta in various flavours using cricket flour.

Tuberculosis is one of the leading causes of death worldwide, with an estimated 1.4 million deaths and ten million people infected annually. Resistant and multidrug-resistant (MDR) variants of the tuberculosis pathogen Mycobacterium tuberculosis pose a major threat to tuberculosis control and global health.

Changes known as epigenetic modifications play an important role in cancer development, among other things. Being able to analyze them quickly and reliably could, for example, contribute significantly to the further development of personalized therapy.

Project BW2Pro - 29/08/2022

Biowaste to Products: biorefinery transforms biowaste into new products

In 2020, Germany’s population collected over 5 million tonnes of biowaste. Most of this was composted, and some was fermented into biogas. Scientists in Baden-Württemberg think there's room for more. Within the project ‘Biowaste to Products’ (BW2Pro) they want to transform biowaste into new products in a biorefinery. The idea is to produce biodegradable plant pots, mulch material, fertilisers, enzymes and biobased plastics in addition to…

CureVac N.V., a global biopharmaceutical company developing a new class of transformative medicines based on mRNA, today announced the start of a Phase 1 study of the modified COVID-19 mRNA vaccine candidate CV0501, administered as a booster dose to previous COVID-19 vaccination. Developed in collaboration with GSK, CV0501 is based on CureVac’s second-generation mRNA backbone and is designed to specifically protect against the Omicron variant.

University of Tübingen team discovers how malformations of the blood vessels can occur in mice – yielding information with possible ramifications for retinal disease.

In mice, inflammation in early to mid-life leads to a permanent decline in functional blood stem cells, according to a recent publication by scientists from the German Cancer Research Center (DKFZ) and the Stem Cell Institute HI-STEM*. The ability of the blood stem cells to regenerate was suppressed for at least one year after challenge with inflammation.

A centre for model-based artificial intelligence has been set up at Heidelberg University to link mathematical modelling methods with information processing in neuronal networks. The Carl Zeiss Foundation (CZS) is funding the CZS Heidelberg Center for Model-Based AI with five million euros over a period of six years.

RHEACELL GmbH - 28/07/2022

Innovative stem cell therapy for chronic wounds

Non-healing, chronically inflamed wounds can be very painful and carry the risk of serious infections. The Heidelberg company RHEACELL has developed a unique drug based on ABCB5-positive mesenchymal stem cells that helps reprogramme the relevant immune cells and promote healing.

Carbon sequestration - 28/07/2022

Carbon farming - climate protection on agricultural land?

Agriculture plays a key role in helping to achieve European climate targets. Central to this goal are measures that are collectively referred to as carbon farming and are often used for offsetting greenhouse gas emissions. Two Baden-Württemberg companies - CarboCert and Carbonfuture - are active in addressing the challenges and potentials of carbon farming.

In Provence, the lavender fields are in full bloom again. This blaze of color may soon also be seen in Baden-Württemberg. In a joint research project, the German Institutes of Textile and Fiber Research Denkendorf (DITF), the University of Hohenheim and the company naturamus are testing suitable lavender varieties and developing energy-efficient methods for producing essential oil from them.

Organ-on-chip for the analysis of drug effects - 20/07/2022

New 3D cell platform allows continuous metabolic monitoring

Organ-on-chips systems are systems containing miniature tissues grown inside mircrofluidic chips. By integrating microsensors, researchers at the IMTEK Freiburg, together with the RWTH Aachen University Hospital, created a novel variant that allows the measurement of metabolic activity directly on site and in real time. This enables the rapid and detailed analysis of drug effects outside an organism.

AaviGen GmbH: Hope for heart failure - 14/07/2022

Gene therapy for weakened hearts

Treating a weak heart – for example after a heart attack – at the GP’s surgery with a single intravenous injection, without causing serious side effects: what sounds almost too good to be true is actually already under development. The Heidelberg-based biotech company AaviGen is working on a platform technology based on adeno-associated viruses that can help introduce therapeutic genes in a highly specific way into diseased heart muscle cells.

Biotech in outer space - 06/07/2022

yuri, a space start-up: weightlessness for commercial research

Growing cells without the effect of gravity could revolutionise drug development. A start-up called yuri on Lake Constance enables made-to-measure experiments on the ISS for stem cells, artificial organs, surfaces and materials. On board the next mission are some mini-cell labs from Berlin's Charité and Goethe University Frankfurt.

Hearing loss - 29/06/2022

Innovative micro loudspeaker brings back hearing

Hearing loss often severely restricts the lives of those affected and can only be partially reversed with conventional hearing aids. The innovative hearing aid developed by Vibrosonic GmbH from Mannheim transmits sound vibrations directly to the eardrum and can thus almost completely restore the natural hearing experience.

Mitochondria are the power plants of cells, and they contain their own genetic material and RNA molecules. Scientists from the German Cancer Research Center (DKFZ) have now discovered that certain modifications in mitochondrial RNA boost the invasive spread of cancer cells by supporting protein synthesis in mitochondria.

Paludiculture as a beacon of hope for the climate - 28/06/2022

Peatlands as CO2 reservoirs: simultaneous renaturation and use

Peatlands store more carbon dioxide than any other ecosystem in the world. However, when drained, they become a climate-damaging source of CO2. The management of wet peatlands reveals exciting solutions, with market potential in the areas of local heating, insulation, packaging and even peat substitution.

Does COVID-19 vaccination increase the risk of cancer patients undergoing therapy with immune checkpoint inhibitors to suffer a dangerous immune complication known as a "cytokine release syndrome"? A team of Heidelberg physicians and scientists has now shown in a clinical study: Increased serum levels of the characteristic cytokines occur frequently in cancer patients, but clinically relevant cases of the dreaded syndrome were not…

Press release - 22/06/2022

Concluding conference of the ARDIA-Net Interreg project

On May 11, the concluding conference of the ARDIA-Net Interreg project took place with 18 in-person attendees in Milan and 18 online participants. The programme for the half-day event included presentations and two panels on the project results as well as discussions on further cross-regional cooperation.

Assay to support the diagnosis of autoimmune diseases - 22/06/2022

Tracking down pathogenic immune complexes

Soluble complexes of antibodies and their target structures circulating in the blood can trigger serious systemic inflammations. Dr. Philipp Kolb and Haizhang Chen from the Institute of Virology at the Freiburg University Medical Centre have developed a sensitive, cell-based test system for detecting these immune complexes. The system can be used to diagnose systemic autoimmune diseases, and also severe cases of COVID-19.

Scientists from the 2. Physics Institute at the University of Stuttgart and the Max Planck Institute for Medical Research were now able to take the next step towards synthetic cells: They introduced functional DNA-based cytoskeletons into cell-sized compartments and showed functionality. The results were recently published in Nature Chemistry.

Alzheimer's, Parkinson's and other neurodegenerative diseases are associated with inflammatory processes in the brain. German researchers have succeeded in identifying a group of proteins in the liquor that could provide information about such inflammatory processes. As so-called biomarkers, the proteins could help to better understand disease processes in the future and to test the effect of potential drugs against brain inflammation.

Renaturalised peatlands as carbon dioxide stores - 14/06/2022

Peatlands as a climate protection factor - binding CO2 instead of releasing it

All intact peatlands on our planet store twice the amount of CO2 as all forests. Peatlands are indispensable for preventing and mitigating the effects of climate change. The only problem is that 95 percent of Germany's peatlands have been drained, and thus release around 7 percent of Germany’s total CO2 emissions into the atmosphere. Rewetting is therefore imperative for the climate, the environment and biodiversity – and economically…

Robot arm for greater accuracy - 08/06/2022

guidoo: robotic assistance for fast and precise biopsies

Needle-based procedures through the skin, such as biopsies of internal organs, not only require a great deal of skill and experience, but they also take time. Fraunhofer IPA Mannheim, together with BEC GmbH from Pfullingen, is developing a robotic surgical assistance system that supports the correct positioning and angulation of a needle with the help of a guide sleeve. This significantly speeds up the procedure while maintaining precision.

The nuclease Cas13b associated with the CRISPR gene scissors, which is an enzyme that degrades nucleic acids, has the potential to be used in the future in hereditary diseases to switch off unwanted genes. In the fight against infections, this nuclease is also being researched as an antiviral agent, as Cas13b can specifically intervene in the genetic material of viruses and render them harmless.

Dr. Nicole Hoffmeister-Kraut, Minister of Economic Affairs, Labour and Tourism of Baden-Württemberg, together with Freiburg’s Mayor Martin Horn, gives the go-ahead for the construction project on the Georges-Köhler-Allee.

Bakteriocins - 24/05/2022

New antibiotic alternatives from soil bacteria

Bacteria are not the greatest of friends among themselves: many release antimicrobial substances into their environment in order to gain an advantage in their ecological niche. Researchers at the University of Ulm are making use of such bacteriocins by creating a genetically modified soil bacterium that can be used as a biotechnological platform organism to produce alternatives to antibiotics in pure form and in large quantities. The fact this…

Lentil cultivation in a producers’ association - EIP-AGRI Rhizo-Linse project - 23/05/2022

From cultivation to market – lentils from the Swabian Alb

Complicated cultivation, fluctuating yields and complex cleaning: Leisa – as lentils are called in Swabian – are demanding. So to produce lentils economically, 130 farmers in the Swabian Alb have joined forces and set up the organic producers’ association Alb-Leisa. Their lentil harvests are processed and marketed by a company called Lauteracher Alb-Feld-Früchte.

The construction industry consumes large amounts of energy resources and produces tons of waste. At the Solar Decathlon Europe 21/22 university competition, students and researchers from KIT are eager to demonstrate that the building sector is already compatible with a functioning circular economy. The task of the interdisciplinary “RoofKIT” team is to convert previously unused roofs of buildings into usable spaces.

Microrobots have the potential to revolutionize medicine. Researchers at the Max Planck ETH Centre for Learning Systems have now developed an imaging technique that for the first time recognises cell-sized microrobots individually and at high resolution in a living organism. This is an important step towards precise control of the robots and their clinical translation.