PixelBiotech GmbH - 27/07/2021

Searching for tracks with cytogenetics and AI

The startup Pixelbiotech combines fluorescence techniques with artificial intelligence to detect DNA and RNA in medical samples. HuluFISH is the name of the method, which allows for countless applications - from detecting viral infections, such as COVID-19 or African swine fever virus, to the quality control of gene and immunotherapeutic procedures in cancer medicine.

Scientists from the German Cancer Research Center and Heidelberg University Hospital have for the first time been able to delay the development of hereditary colorectal cancer with a protective vaccination. Mice with a hereditary predisposition to colorectal cancer survived significantly longer after vaccination than unvaccinated animals. Combining the vaccination with an anti-inflammatory drug increased the protective effect.

Gene regulation - 20/07/2021

The many faces of the epigenetic regulator MOF

Epigenetic modifications play a crucial role in coordinated gene transcription, and are required for a fertilised egg cell to be able to develop into an organism with different cell types. Dr. Asifa Akhtar from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg has been studying the essential epigenetic regulator protein MOF for 20 years.

The "livMatS Pavilion" in the Botanical Garden of the University of Freiburg is a model for a bioinspired sustainable construction. In a joint project, researchers from the Universities of Freiburg and Stuttgart together with master’s students from the University of Stuttgart have designed a lightweight pavilion.

To diagnose an infection with the coronavirus, usually a throat swab is taken and genetic viral material detected by using a highly sensitive PCR. To date, more than 65 million of these tests have been performed in Germany alone. Due to the massive increase in testing worldwide and simultaneous loss of production, there was a significant shortage of test materials in the early stage of the pandemic.

Under certain conditions, our immune system can efficiently fight off infectious diseases and cancer. T cells, especially the gamma delta T cell type, play an important role in this. The issue is that this cell type is extremely infrequent in the human body. Researchers at the University Hospital Tübingen, the University of Heidelberg and the European Molecular Biology Laboratory (EMBL) have now succeeded in finding the cause for the formation of…

Age-related macular degeneration (AMD) is the commonest cause of blindness in developed countries affecting seven million in total in Germany, from which 500,000 people are suffering from late stage disease, around half of whom are registered as visually impaired. There are two forms of AMD, ‘wet’ and ‘dry’. There are currently no treatments available for the dry form of the disease (geographic atrophy).

Through a complex, self-reinforcing feedback mechanism, colorectal cancer cells make room for their own expansion by driving surrounding healthy intestinal cells to death - while simultaneously fueling their own growth. This feedback loop is driven by an activator of the innate immune system. Researchers from the German Cancer Research Center (DKFZ) and the University of Heidelberg discovered this mechanism in the intestinal tissue of fruit…

Refuels are renewable fuels that can be produced in different ways. When they are mixed and processed such that they meet the existing fuel standards, they are suited for all types of combustion engines. This is the result of the latest vehicle and fleet tests within the project “reFuels – Rethinking Fuels” at Karlsruhe Institute of Technology (KIT). Compared to fully fossil fuels, refuel mixes allow for a CO2 reduction by 25% at least. Moreover,…

Article - 08/07/2021

Individual operation risk assessment by the Cognitive Medical Assistant

Despite modern surgical techniques and anaesthetic procedures, serious complications can occur during surgical interventions. An interdisciplinary team at Heidelberg University Hospital has launched a project called the Cognitive Medical Assistant (German: Der Kognitive Medizinische Assistant, KoMed for short), designed to better assess the individual risk of these interventions. The project’s goal is to systematically and comprehensively analyse…

The European Union is largely dependent on imports of white phosphorus (P4), a strategic raw material for the food and pharmaceutical industries. To tackle this challenge, the newly started four-year EU-funded project FlashPhos – led by the University of Stuttgart – will recover at a large scale high-quality white phosphorus and other raw materials using sewage sludge as input material.

Scientists from the EMBL and the German Cancer Research Center have presented a new method for generating metabolic profiles of individual cells. The method, which combines fluorescence microscopy and a specific form of mass spectroscopy, can analyze over a hundred metabolites and lipids from more than a thousand individual cells per hour. Researchers expect the method to better answer a variety of biomedical questions in the future.

Start-up kernique catch the zeitgeist - 29/06/2021

Nut snack as a sustainable ecological concept

A delicious vegan nut snack that uses no sugar, artificial additives, gluten or palm oil, is full of essential nutrients, and is part of a commitment to environmental and social sustainability. Impossible? An Esslingen-based start-up called kernique proves otherwise. The start-up is currently planning a crowdfunding phase that offers a lucrative deal for investors. The idea catches the zeitgeist, but what exactly makes it stand out?

For the first time, scientists from the German Cancer Consortium (DKTK) partner site in Essen/Düsseldorf have discovered stem cells of the hematopoietic system in glioblastomas, the most aggressive form of brain tumor. These hematopoietic stem cells promote division of the cancer cells and at the same time suppress the immune response against the tumor.

Article - 22/06/2021

Using virtual reality in the clinic to rehabilitate patients with cognitive disorders

Outdated and inadequate methods of neurological rehabilitation are still being used for patients with neurological diseases or injuries – and what’s more, the treatment is usually too late. This is because cognitive training is especially important in the critical phases when the brain is particularly plastic. The Heidelberg-based company living brain proves that early treatment is possible using an extremely innovative method – with concentrated…

The EU funded research project HyFlexFuel recently succeeded to produce biocrudes via hydrothermal liquefaction (HTL) from a variety of biomasses, including sewage sludge, food waste, manure, wheat straw, corn stover, pine sawdust, miscanthus and microalgae in a pilot-scale continuous HTL plant at Aarhus University (Denmark).

Which neurons in the brain mediate fear responses - and how do they flip the switch when the danger is over? The research team of Prof. Ingrid Ehrlich at the Institute of Biomaterials and Biomolecular Systems (IBBS), Department of Neurobiology studies these questions. Their latest results obtained in collaboration with scientists at the Friedrich Miescher Institute in Basel (Switzerland), the National Institute of Health (USA), and Innsbruck…

CureVac N.V. (Nasdaq: CVAC), a clinical-stage biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (“mRNA”), today announced results of the second interim analysis of its international pivotal Phase 2b/3 study in approximatively 40,000 subjects (the HERALD study) of CureVac’s first-generation COVID-19 vaccine candidate, CVnCoV.

It is not the first time that spiders have served as biological models in the research field of soft robotics. The hydraulic actuation mechanisms they apply to move their limbs when weaving their web or hunting for prey give them powers many roboticists and engineers have drawn inspiration from.

Microorganisms are the oldest, most abundant, and most diverse life forms on earth and offer enormous potential for biotechnological applications. To date, however, only a fraction of them could be isolated and cultivated. The “MicroMATRIX” research project, funded with € 1.5 million by the German Federal Ministry of Education and Research and led by Karlsruhe Institute of Technology (KIT), aims to shed more light on the microbial darkness.

Effective drugs for the treatment of diseases of the central nervous system do exist. However, the blood-brain barrier, which protects the brain as the body's control center, makes it especially difficult for therapeutic biomolecules to pass through. Thus, researchers from an international consortium coordinated by the Fraunhofer IGB have spent the last four and a half years developing a novel system in the EU project "N2B-patch"…