Start-up PROSERVATION - sustainable packaging - 21/09/2021

Husk as a substitute for polystyrene: packaging materials with a good conscience

Expanded polystyrene (EPS) packaging is very practical, but it is made from petroleum and is not very environmentally friendly in other ways either. Single-use plastic containers made of EPS have therefore been banned in the EU, but alternatives are also urgently needed. The Stuttgart-based start-up PROSERVATION has developed an ecological packaging material made from grain husks that could replace EPS and be just as effective.

A team of engineers and biotechnologists at the University of Freiburg has for the first time shown in mammals that the concentration of antibiotics in the body can be determined using breath samples. The breath measurements also corresponded to the antibiotic concentrations in the blood. The team’s biosensor – a multiplex chip – will in future enable personalized dosing of medicines against infectious diseases on-site.

Cyber Valley researchers have created medical educational tools that could potentially train the surgeons of the future, much like flight simulators train pilots. The team developed a range of artificial organ phantoms to serve as training platforms for surgeons. Thanks to the structured data of experienced medical professionals, a quantitative and objective assessment of a trainee’s skills can be assessed in real time.

Personalised medicine - 16/09/2021

Pharmacogenomics enables individualised drug prescription

Every person is unique, and their reaction to medications can be just as individual. For this reason, unexpected side effects occur time and again with common drugs, sometimes with life-threatening consequences. At the Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology (IKP) in Stuttgart, the influence of hereditary factors on these harmful reactions is being investigated in order to enable individualised therapies.

Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have developed antibodies that have two antigen-binding sites and can couple cancer cells with effector cells of the immune system. In laboratory tests, these bridging antibodies, together with an enhancer antibody, were able to specifically mobilize the body's own immune defenses and destroy breast cancer cells.

Scientists use super-resolution microscopy to study previously undiscovered cellular worlds, revealing nanometer-scale details inside cells. This method revolutionized light microscopy and earned its inventors the 2014 Nobel Prize in Chemistry. In an international collaboration, AI researchers from Tübingen have now developed an algorithm that significantly accelerates this technology.

Christiane Opitz, scientist at the German Cancer Research Center, is being awarded this year's Ita Askonas Prize of the European Federation of Immunological Societies. Opitz has discovered how tumor cells use certain metabolites to protect themselves against the immune system. Her research findings may provide important clues for the development of new therapeutic concepts.

On the one hand, blood vessels supply tumors with nutrients and, on the other, enable cancer cells to spread throughout the body. The settlement of circulating tumor cells in a distant organ is promoted by factors whose production is induced by the primary tumor itself. Scientists have now identified a new growth factor produced by blood vessels that enables tumor cells to metastatically colonize organs.

As a rapidly growing renewable raw material, bamboo is an ideal substitute for wood. However, bamboo’s susceptibility to mold in damp conditions poses a problem. Researchers at Fraunhofer have now analyzed bamboo’s response to moisture under specific climatic conditions. By using simulation software, building owners can plan and implement measures to prevent the growth of mold.

Reduction of greenhouse gases in wine production - 31/08/2021

The REDWine project and climate change

In the EU project REDWine, the CO2 produced during wine fermentation is captured and used to produce algae biomass. Novis GmbH from Tübingen supplies the complete system for CO2 utilisation. The aim of the project is to reduce the share of global warming caused by wine production in a way that is economical for producers.

Expert interview - 31/08/2021

Health Data Scenarios - many possibilities for the future?

The digitization of healthcare is progressing slowly but steadily. In addition to simple telemedical applications, data such as electronic patient records are forming the basis of digitization. The ‘Health Data Scenarios’ project aims to model the future of healthcare data by using scenarios. Lucas Scherdel, Healthcare Innovation Director at DayOne, and Dr. Alexander Fink, founder and CEO of ScMI AG, explain how this will work.

CureVac N.V. (Nasdaq: CVAC), a global biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (“mRNA”), today announced the publication entitled “Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model” in the peer-reviewed Journal of Hepatology.

In August 2021, the BioMat Pavilion 2021 was inaugurated on the campus of the University of Stuttgart in a ceremonial setting and in compliance with the hygiene concept. The core of the elegantly curved lightweight construction is an active-bending structure made of natural fibers, reminiscent of bamboo. It was developed as part of the "LeichtPRO" research project.

An international research team has calculated the potential for material efficiency strategies in residential buildings and passenger cars. Up to two-thirds of global emissions could be saved in these areas, provided that appropriate strategies are consistently implemented.

New drugs are intended to help stop viral zoonoses – infections that jump from animals to humans. To study suitable inhibitors, Prof. Dr Christian Klein from the Institute of Pharmacy and Molecular Biotechnology (IPMB) of Heidelberg University is receiving funding in the amount of 450,000 euros from the Volkswagen Foundation.

3R-Center - 18/08/2021

Putting alternatives to animal testing into practice

Animal experiments are still central to biomedical research. However, it has become increasingly clear that not all of them are absolutely necessary. Alternative techniques exist. The new 3R-Netzwerk Baden-Württemberg is now seeking to promote these more vigorously - and improve animal welfare in cases where alternatives to animal testing are not available.

The risk of colorectal cancer can be predicted more accurately by determining seven blood-based micro-RNAs (miRNAs) than by using traditional methods - and can be done so many years before a diagnosis is made. In a current study, researchers from the German Cancer Research Center and the National Center for Tumor Diseases (NCT) Heidelberg show that miRNA profiles provide greater predictive accuracy than genetic or lifestyle-based risk…

As a dominant part of southern Germany’s life-science industry hub, Heidelberg will soon have a life-science startup incubator of its own. BioLabs, the premier US network of managed co-working lab space, will open its first German branch in the Heidelberg Innovation Park (hip). On August 16, representatives of city and state governments, BioLabs and the life-science industry celebrated the Heidelberg BioLabs groundbreaking.

Plastics from the field - 12/08/2021

Great potential for biological residues

Huge amounts of waste are produced both during food production and by consumers. The Conversion Technologies of Biobased Resources group at the University of Hohenheim’s Institute of Agricultural Engineering has developed a process to convert this biomass into hydroxymethylfurfural (HMF), the highly potent basic chemical that is used to produce plastics.

Workplace of the future - 10/08/2021

Intelligent body support system for surgery staff

Operating room staff often spend hours in strenuous postures, which has a significant impact on concentration and quality of work. While operating room equipment is increasingly networked, state-of-the-art medical technology, conditions for operating room staff trail way behind. The start-up company Hellstern medical offers an effective solution for serious pain, fatigue and incorrect interventions.

Digitalisation - 04/08/2021

Eye check for all - quick and easy thanks to artificial intelligence

Many eye diseases are already easily treatable, if they are detected in time. But waiting months for an ophthalmologist’s appointment seems to be the norm - that is, if you can get to see a specialist at all. The Tübingen-based start-up eye2you wants to improve this situation: it has developed a mobile retinal examination device involving a smartphone and AI. It can be used by family doctors, diabetologists and nursing staff and thus help to…

ROKO Farming - 03/08/2021

Thinking upwards: vertical farming to be further developed into continuous production

ROKO Farming’s novel technology is designed to produce fruit and vegetables worldwide all year round, while also freeing up areas for rewilding. This semi-automatic production method created by the Ulm-based business has huge future potential, as their success in innovation competitions demonstrates.

Carbon dioxide is one of the main drivers of climate change – which means that we need to reduce CO2 emissions in the future. Fraunhofer researchers are highlighting a possible way to lower these emissions: They use the greenhouse gas as a raw material, for instance to produce plastics. To do this, they first produce methanol and formic acid from CO2, which they convert via microorganisms into building blocks for polymers and the like.

The Hallertau is Germany's largest hop-growing region. During harvesting, hop bine chaff is left over, which is converted into environmentally friendly bio natural gas on site in a biogas plant. But that is not the end of the utilization chain for this fiber plant. Researchers at the German Institutes of Textile and Fiber Research Denkendorf (DITF) have used the plant-containing biogas digestate to produce a composite material that can be…

Alpha-Protein GmbH - 27/07/2021

Insect farming for sustainability

Mealworms instead of fish meal and soybean meal - this is what the sustainable future of feed production looks like as Alpha-Protein GmbH see it. The company has built a highly efficient automated production plant in which residual materials from local food production are used to breed mealworms.

PixelBiotech GmbH - 27/07/2021

Searching for tracks with cytogenetics and AI

The startup Pixelbiotech combines fluorescence techniques with artificial intelligence to detect DNA and RNA in medical samples. HuluFISH is the name of the method, which allows for countless applications - from detecting viral infections, such as COVID-19 or African swine fever virus, to the quality control of gene and immunotherapeutic procedures in cancer medicine.

Scientists from the German Cancer Research Center and Heidelberg University Hospital have for the first time been able to delay the development of hereditary colorectal cancer with a protective vaccination. Mice with a hereditary predisposition to colorectal cancer survived significantly longer after vaccination than unvaccinated animals. Combining the vaccination with an anti-inflammatory drug increased the protective effect.

Gene regulation - 20/07/2021

The many faces of the epigenetic regulator MOF

Epigenetic modifications play a crucial role in coordinated gene transcription, and are required for a fertilised egg cell to be able to develop into an organism with different cell types. Dr. Asifa Akhtar from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg has been studying the essential epigenetic regulator protein MOF for 20 years.

The "livMatS Pavilion" in the Botanical Garden of the University of Freiburg is a model for a bioinspired sustainable construction. In a joint project, researchers from the Universities of Freiburg and Stuttgart together with master’s students from the University of Stuttgart have designed a lightweight pavilion.

To diagnose an infection with the coronavirus, usually a throat swab is taken and genetic viral material detected by using a highly sensitive PCR. To date, more than 65 million of these tests have been performed in Germany alone. Due to the massive increase in testing worldwide and simultaneous loss of production, there was a significant shortage of test materials in the early stage of the pandemic.

Under certain conditions, our immune system can efficiently fight off infectious diseases and cancer. T cells, especially the gamma delta T cell type, play an important role in this. The issue is that this cell type is extremely infrequent in the human body. Researchers at the University Hospital Tübingen, the University of Heidelberg and the European Molecular Biology Laboratory (EMBL) have now succeeded in finding the cause for the formation of…

Age-related macular degeneration (AMD) is the commonest cause of blindness in developed countries affecting seven million in total in Germany, from which 500,000 people are suffering from late stage disease, around half of whom are registered as visually impaired. There are two forms of AMD, ‘wet’ and ‘dry’. There are currently no treatments available for the dry form of the disease (geographic atrophy).

Through a complex, self-reinforcing feedback mechanism, colorectal cancer cells make room for their own expansion by driving surrounding healthy intestinal cells to death - while simultaneously fueling their own growth. This feedback loop is driven by an activator of the innate immune system. Researchers from the German Cancer Research Center (DKFZ) and the University of Heidelberg discovered this mechanism in the intestinal tissue of fruit…

Refuels are renewable fuels that can be produced in different ways. When they are mixed and processed such that they meet the existing fuel standards, they are suited for all types of combustion engines. This is the result of the latest vehicle and fleet tests within the project “reFuels – Rethinking Fuels” at Karlsruhe Institute of Technology (KIT). Compared to fully fossil fuels, refuel mixes allow for a CO2 reduction by 25% at least. Moreover,…

Article - 08/07/2021

Individual operation risk assessment by the Cognitive Medical Assistant

Despite modern surgical techniques and anaesthetic procedures, serious complications can occur during surgical interventions. An interdisciplinary team at Heidelberg University Hospital has launched a project called the Cognitive Medical Assistant (German: Der Kognitive Medizinische Assistant, KoMed for short), designed to better assess the individual risk of these interventions. The project’s goal is to systematically and comprehensively analyse…

The European Union is largely dependent on imports of white phosphorus (P4), a strategic raw material for the food and pharmaceutical industries. To tackle this challenge, the newly started four-year EU-funded project FlashPhos – led by the University of Stuttgart – will recover at a large scale high-quality white phosphorus and other raw materials using sewage sludge as input material.

Scientists from the EMBL and the German Cancer Research Center have presented a new method for generating metabolic profiles of individual cells. The method, which combines fluorescence microscopy and a specific form of mass spectroscopy, can analyze over a hundred metabolites and lipids from more than a thousand individual cells per hour. Researchers expect the method to better answer a variety of biomedical questions in the future.

Start-up kernique catch the zeitgeist - 29/06/2021

Nut snack as a sustainable ecological concept

A delicious vegan nut snack that uses no sugar, artificial additives, gluten or palm oil, is full of essential nutrients, and is part of a commitment to environmental and social sustainability. Impossible? An Esslingen-based start-up called kernique proves otherwise. The start-up is currently planning a crowdfunding phase that offers a lucrative deal for investors. The idea catches the zeitgeist, but what exactly makes it stand out?

For the first time, scientists from the German Cancer Consortium (DKTK) partner site in Essen/Düsseldorf have discovered stem cells of the hematopoietic system in glioblastomas, the most aggressive form of brain tumor. These hematopoietic stem cells promote division of the cancer cells and at the same time suppress the immune response against the tumor.

Article - 22/06/2021

Using virtual reality in the clinic to rehabilitate patients with cognitive disorders

Outdated and inadequate methods of neurological rehabilitation are still being used for patients with neurological diseases or injuries – and what’s more, the treatment is usually too late. This is because cognitive training is especially important in the critical phases when the brain is particularly plastic. The Heidelberg-based company living brain proves that early treatment is possible using an extremely innovative method – with concentrated…

The EU funded research project HyFlexFuel recently succeeded to produce biocrudes via hydrothermal liquefaction (HTL) from a variety of biomasses, including sewage sludge, food waste, manure, wheat straw, corn stover, pine sawdust, miscanthus and microalgae in a pilot-scale continuous HTL plant at Aarhus University (Denmark).

Which neurons in the brain mediate fear responses - and how do they flip the switch when the danger is over? The research team of Prof. Ingrid Ehrlich at the Institute of Biomaterials and Biomolecular Systems (IBBS), Department of Neurobiology studies these questions. Their latest results obtained in collaboration with scientists at the Friedrich Miescher Institute in Basel (Switzerland), the National Institute of Health (USA), and Innsbruck…

CureVac N.V. (Nasdaq: CVAC), a clinical-stage biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (“mRNA”), today announced results of the second interim analysis of its international pivotal Phase 2b/3 study in approximatively 40,000 subjects (the HERALD study) of CureVac’s first-generation COVID-19 vaccine candidate, CVnCoV.

It is not the first time that spiders have served as biological models in the research field of soft robotics. The hydraulic actuation mechanisms they apply to move their limbs when weaving their web or hunting for prey give them powers many roboticists and engineers have drawn inspiration from.

Microorganisms are the oldest, most abundant, and most diverse life forms on earth and offer enormous potential for biotechnological applications. To date, however, only a fraction of them could be isolated and cultivated. The “MicroMATRIX” research project, funded with € 1.5 million by the German Federal Ministry of Education and Research and led by Karlsruhe Institute of Technology (KIT), aims to shed more light on the microbial darkness.

Effective drugs for the treatment of diseases of the central nervous system do exist. However, the blood-brain barrier, which protects the brain as the body's control center, makes it especially difficult for therapeutic biomolecules to pass through. Thus, researchers from an international consortium coordinated by the Fraunhofer IGB have spent the last four and a half years developing a novel system in the EU project "N2B-patch"…