Do BMMFs, the novel infectious agents found in dairy products and bovine sera, play a role in the development of colorectal cancer? Scientists led by Harald zur Hausen detected the pathogens in colorectal cancer patients in close proximity to tumors. The researchers show that the BMMFs trigger local chronic inflammation, which can cause mutations via activated oxygen molecules and thus promote cancer development in the long term.

Article - 05/03/2019

Vaccination against oncogenic Epstein-Barr viruses

Almost all humans are infected with Epstein-Barr viruses (EBV), which are linked to the development of benign diseases such as infectious mononucleosis as well as several cancers. Scientists from the German Cancer Research Center have developed a new strategy for creating a vaccine that targets different EBV virus life phases and has the potential to provide effective protection against EBV infection.

Dossier - 19/10/2022

More food sustainability: crucial for people and for the environment

Strawberries in winter and imported apples? You can find them in most supermarkets. This is not sustainable. Looking to the future, the way we eat needs to change in many mundane ways – and this needs to happen quickly so that future generations will also be able to enjoy a planet that is worth living on. In Baden-Württemberg, alternative nutrition concepts are being worked at pace. Many creative ideas and innovative products already exist.

ProGrün project - 30/12/2023

Using proteins extracted from grassland cuttings to produce animal feed and exploit by-product streams

Animal feed often contains protein from soy and importing it causes major environmental harm. In the ProGrün project, researchers at the University of Hohenheim, including a work group led by Prof. Dr. Andrea Kruse, are developing a scalable technological process to extract proteins from grassland cuttings and use them to make sustainable animal feed produced in the region where it will be used.

The Deep-Tech Start-Up memetis GmbH from Germany, which produces the world’s most compact and lightest commercially available valves driven by shape memory alloys, announces a new partnership with Fluid-o-Tech S.r.l., an Italian innovation and market leader in the field of fluid-pumps.

As healthy and tasty as mushrooms might be, they are good for much more than just the dinner plate. The Fraunhofer Institute for Environmental, Safety and Energy Technology UMSICHT has now teamed up with the Fraunhofer Institute for Building Physics IBP to investigate the use of fungus-based materials for the fabrication of eco-friendly sound absorbers.

An international research team has calculated the potential for material efficiency strategies in residential buildings and passenger cars. Up to two-thirds of global emissions could be saved in these areas, provided that appropriate strategies are consistently implemented.

Industrial biocatalysis with enzymes is deemed to be a “game changer” in the development of a sustainable chemical industry. Enzymes can be used to synthesize an impressive range of complex molecules. Researchers of KIT have now developed a new class of materials by producing enzyme foams of tremendous stability and activity. The researchers have already filed a patent application on the process to produce enzyme foams.

Climate-neutral wastewater treatment plants thanks to patented real-time analytics - 08/11/2023

Using AI to reduce greenhouse gases in wastewater companies

The wastewater industry is responsible for global greenhouse gas emissions equivalent to those of global aviation. The start-up Variolytics has found a way to significantly reduce greenhouse gases in wastewater treatment plants using real-time analytics. The patented sensor technology and AI-supported process optimisation offer multiple benefits: in addition to reducing nitrous oxide, the system helps to reduce energy costs and resources.

The results of a Tuebingen-led study raise hope that a newly developed drug could herald a new era in oncological liver surgery and transplantation. The drug could even have the potential to significantly improve the treatment of acute and chronic liver diseases. The drug candidate "HRX-215" is a so-called MKK4 inhibitor, i.e. the drug inhibits the MKK4 protein found in liver cells and thus leads to an increase in the regeneration of…

Bayer has signed a collaboration and services agreement with CureVac, a biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid. Under the terms of the agreement, Bayer will support the further development, supply and key territory operations of CureVac´s COVID-19 vaccine candidate CVnCoV.

Press release - 31/03/2023

Simulation of Miscanthus- and Sorghum-based resilient value chains in the Danube Region

Can the value chains in the Danube macro-region be more sustainable and resilient against disruptions such as pandemics? How modelling could help to simulate the economic viability of developing Miscanthus and Sorghum based value chains in that region?

In August 2021, the BioMat Pavilion 2021 was inaugurated on the campus of the University of Stuttgart in a ceremonial setting and in compliance with the hygiene concept. The core of the elegantly curved lightweight construction is an active-bending structure made of natural fibers, reminiscent of bamboo. It was developed as part of the "LeichtPRO" research project.

Article - 12/03/2019

Biocarbon fibres made of lignin

Carbon fibre is increasingly found in airplanes, cars and wind turbines. Carbon fibre is still made from oil and relatively expensive. However, this is soon to change. Researchers from the German Institutes of Textile and Fibre Research in Denkendorf (DITF) are working on the development of cost-effective carbon fibre made of lignin, a by-product of papermaking.

University of Hohenheim project contributes to maintaining valuable biotopes: Autonomous robot to help prune fruit trees so they stay healthy.

The Ministry of the Environment, Climate Protection and the Energy Sector is funding the KoalAplan project, which extends the functional scope of a wastewater treatment plant. The project, based in the Stuttgart district of Büsnau, aims at recovering raw materials from wastewater and is therefore making a positive contribution to climate neutrality, as the products obtained replace fossil raw materials and energy-intensive processes.

BioFluidix GmbH, a spin-off resulting from the cooperation between Hahn-Schickard and the Department of Microsystems Engineering at the University of Freiburg, is now part of the Swiss Hamilton Bonaduz AG.

The “Rhizo-Lentil" EIP-AGRI project - 03/03/2020

University of Hohenheim wants to improve the conditions for lentil cultivation

Lentils were once considered poor man’s food, but in Germany demand for them has never been greater. And to satisfy this growing demand, more lentils need to be cultivated. This is why the University of Hohenheim is involved in the EIP-AGRI "Rhizo-Linse" project. The aim of the project is to find rhizobia strains that go well with lentil plants to increase yield and improve quality.

With "OrgaPlexing", scientists at the MPI of Immunobiology and Epigenetics have developed a new method that shows how guardian cells of the immune system, the macrophages, orchestrate their cell structures during inflammation or bacterial infection, making it possible to observe the interactions between several organelles simultaneously and thus providing insights into cell metabolism and the production of inflammatory molecules.

Plastic products can be found everywhere in daily life, soft plastic in particular often being used for packaging or children's toys. These often contain so-called plasticizers which ensure that the material remains flexible. Because plasticizers are not bonded permanently to the plastic, they can escape from the material, meaning they can be absorbed by humans.

Press release - 23/09/2022

Phytopharmaceuticals and valuable plant ingredients - opportunities for industry and agriculture in Baden-Württemberg

The "Phytopharmaceuticals and Valuable Plant Ingredients" initiative aims to make the key economic issue of phytopharmaceuticals more visible in Baden-Württemberg in order to gain a better understanding of the challenges and needs of the state’s pharmaceutical industry. The overall goal is to strengthen the use of secondary plant ingredients in valuable products and build on this to develop opportunities for Baden-Württemberg…

Workplace of the future - 10/08/2021

Intelligent body support system for surgery staff

Operating room staff often spend hours in strenuous postures, which has a significant impact on concentration and quality of work. While operating room equipment is increasingly networked, state-of-the-art medical technology, conditions for operating room staff trail way behind. The start-up company Hellstern medical offers an effective solution for serious pain, fatigue and incorrect interventions.

To diagnose an infection with the coronavirus, usually a throat swab is taken and genetic viral material detected by using a highly sensitive PCR. To date, more than 65 million of these tests have been performed in Germany alone. Due to the massive increase in testing worldwide and simultaneous loss of production, there was a significant shortage of test materials in the early stage of the pandemic.

Elastin as artificial muscle material - 02/03/2022

Artificial muscle from proteins for diverse future applications

As far as diversity and complexity are concerned, proteins are nature's smallest marvels. Biotechnologists have already used natural proteins as a basis for the development, bespoke design and production of artificial systems. This is what the livMatS cluster of excellence at the University of Freiburg has been doing. Researchers in the cluster have successfully produced an artificial muscle from elastin that functions autonomously.

3D-Thermocell project - 17/05/2023

Paper instead of plastic: sustainable packaging with a good conscience

Replacing plastic – for example in packaging – is not that easy but nevertheless urgently needed. In the 3D-Thermocell project, researchers at DHBW Karlsruhe are currently developing new plastic substitute products made of thermoformable paper as a renewable resource, which should be cheap and light and easy to dispose of along with waste paper. The characterisation and application of demonstration models will start soon.

Team of Freiburg researchers shows how information about the quantity of absorbed light passes from the leaves to the roots. Plant growth is driven by light and supplied with energy through photosynthesis by green leaves. It is the same for roots that grow in the dark – they receive the products of photosynthesis, in particular sucrose, i.e. sugar, via the central transportation pathways of phloem.

At the Fraunhofer Center for Chemical-Biotechnological Processes CBP in Leuna, Germany, representatives from politics, research and industry opened a novel pilot plant for the mild processing of rapeseed to increase the added-value potential of rape as a raw material.

Development of biogenic packaging - 16/11/2020

Sustainable packaging - the devil is in the detail

Modern packaging often boils down to a tick list of biogenic origin and/or biodegradability. But comprehensive sustainable packaging concepts need more than just that. Perishable foods, for example, require special barrier properties. The Albstadt-Sigmaringen University of Applied Sciences is researching packaging concepts for their sustainability.

Genetically enhancing a patient's immune cells by adding therapeutic genes to them outside the body is regarded as a promising new treatment approach in oncology. However, the production of these therapeutic cells using viruses is not only expensive but time-consuming. Researchers at the German Cancer Research Center (DKFZ) have developed an innovative non-viral vector that can efficiently introduce therapeutic genes into immune cells.

A new study published in Nature Medicine, July 2023 has identified two novel markers for screening high-grade squamous intraepithelial lesions (HSIL), a precursor to anal cancer, from the anal microbiome of people with HIV (PWH). PWH are at a significantly higher risk of developing anal cancer. Current screening methods, such as anal cytology, have low specificity for detecting HSIL, which hinders the prevention of anal cancer.

Product testing under real conditions - 11/05/2022

INSPIRE Living Lab: a bridge between industry and the clinic

Coming up with innovative ideas and products in the medical care area is highly relevant not only for the further development of Baden-Württemberg as a health region, but also for improving healthcare itself. However, bridging the gap between industry and the clinic often proves difficult. To drive this process forward, the INSPIRE Living Lab was opened at the University Medical Centre Mannheim in 2021.

Development of anti-tumour agents - 20/03/2023

Targeting the protective shield of cancers

Cancer cells have different mechanisms to help them escape destruction by the immune system. Solid tumours, for example, are often surrounded by a protective layer of lactate, which has a strong immunosuppressive effect. WMT AG from Heidelberg is developing small drug molecules that reduce lactate production and thus make cancer cells vulnerable to immune system attacks.

Alternative construction materials: mycelium-based materials - 20/12/2023

Using fungi to create sustainable and economical mycelium-based materials

Most of us see fungi as just food - and possibly pathogens. This is a mistake, because these amazing organisms are capable of much more: they grow on plant residues of all kinds, forming a dense and interconnected structure as they spread. The resulting material can be moulded into desired shapes and be turned into new sustainable and economically attractive products such as leather and polystyrene substitutes or building materials.

Urban agriculture - 23/04/2020

alphabeet – the green-fingered smartphone

Given the challenges faced by modern agriculture, it is vital to raise people’s awareness of how to change their approach to food. The founders of the Stuttgart-based start-up company farmee GmbH see urban agriculture as the key to making this change possible. The company has developed “alphabeet”, an app designed to encourage consumers to produce their own food. After all, only those combining knowledge and practical experience can be expected…

Applying and developing new technologies for DNA synthesis to pave the way for producing entire artificial genomes – that is the goal of a new interdisciplinary center, 'Center for Synthetic Genomics', that is being established at Heidelberg University, Karlsruhe Institute of Technology (KIT), and Johannes Gutenberg University Mainz (JGU).

Dossier - 20/03/2017

Lignin – a natural resource with huge potential

Petroleum is the raw material for basic chemicals. Growing demand and dwindling resources mean that the chemical industry is increasingly focusing on renewable resources. Lignin is a wood component that is proving to be a promising resource. It is currently almost exclusively used for generating energy, although it could also be used for other purposes. In Baden-Württemberg, a research consortium is specifically focused on exploring its…

The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is funding a new Emmy Noether junior research group at the DKFZ for six years with a total of around 2 million euros. The scientists and doctors, who are part of the Clinical Cooperation Unit for Pediatric Leukemia at the KiTZ, are using a new procedure to investigate how cancer cells manipulate the formation of proteins to become resistant to cancer drugs.

This year's Venice Architecture Biennale sees itself as a "Laboratory of the Future". Bio-composites are not just dreams of the future in architecture. The German Institutes of Textile and Fiber Research (DITF) have developed a sustainable material for support profiles and connecting nodes, which will be on display at Palazzo Mora during the Biennale from May 20 to November 26.

In the “Cluster4Future” QSens of the Universities of Stuttgart and Ulm, scientists, companies and start-ups are researching quantum sensors with a wide range of potential applications. The Federal Ministry of Education and Research is funding QSens for a further three years as part of “Clusters4Future”.

CRISPR/Cas9 and genetic engineering laws - 27/11/2019

Transgene-free plant breeding using genome editing

Plant geneticists from Tübingen have used genome deletion to breed a variety of tomato that is resistant to powdery mildew. The CRISPR/Cas9 technology that they used enabled them to achieve this in a relatively short period of time. They also demonstrated beyond any doubt that the new tomato variety contains no foreign DNA and is indistinguishable from naturally occurring deletion mutants.

On the one hand, blood vessels supply tumors with nutrients and, on the other, enable cancer cells to spread throughout the body. The settlement of circulating tumor cells in a distant organ is promoted by factors whose production is induced by the primary tumor itself. Scientists have now identified a new growth factor produced by blood vessels that enables tumor cells to metastatically colonize organs.

Dossier - 22/10/2012

Environmental biotechnology

Biotechnologists are increasingly learning how to apply the knowledge about biological metabolic processes in the field of environmental protection including waste management and environmental rehabilitation. Environmental biotechnology is a field with great potential. In future bacteria and other microorganisms will most likely also contribute to sustainability and cost efficiency in other areas including the cosmetics and detergent industry as…

Dossier - 15/11/2019

Microplastics waste is a valuable resource – it is just in the wrong place

The negative image of plastic persists and is not getting any better in the face of the ongoing debate about microplastics which are basically everywhere. Plastic pollutes the environment. The globe is littered with huge quantities. We have to modify the production and utilisation of macroplastics as well as fundamentally rethink the way we dispose of them. ‘Out of sight, out of mind’ mentality must become a thing of the past.

EIP-AGRI project coordination - 12/12/2019

nadicom: “Rhizo-Linse” project – excellent small fertiliser factories

Lentil plants, rarely cultivated in Central Europe in the twentieth century, are making a comeback. The "Rhizo-Linse"1 EIP-AGRI project aims to reintroduce old lentil varieties and make them appealing to farmers. A company called nadicom Gesellschaft für angewandte Mikrobiologie mbH is working on the development of an ecological product consisting of nodule bacteria that can improve lentil plant growth.

The AlbLavendel project - 20/11/2023

Swabian lavender cultivation: aesthetic and sustainable

Blue-violet, fragrant fields like those in Provence may soon become a common sight in the Swabian Alb. As part of the AlbLavendel project, the University of Hohenheim along with the company naturamus GmbH and the German Institutes of Textile and Fibre Research Denkendorf has started to investigate the cultivation of lavender, the production of essential oils and the use of distillation residues for producing textile fibres in the local region.

The University of Stuttgart is contributing to innovations for climate protection as part of the EU project "Smart Circular Bridge". An old material is being rediscovered: flax has been with us for thousands of years in the form of clothing, sacks, and robust ship's ropes. Now the plant fibres are experiencing a renaissance and could become the building material of the future.