Konstanz researchers discover the function of a previously unexplored protein: In three characteristic steps, "C12orf29" links the ends of RNA strands. Proteins that perform this kind of RNA ligation were previously unknown in humans. The results of the study suggest that it is important for RNA repair during cellular stress.

In collaboration with the project partners CG TEC, Cordenka, ElringKlinger, Fiber Engineering and Technikum Laubholz, the DITF are developing a new fiber composite material (CELLUN) with reinforcing fibers made of cellulose. The matrix of the material is a thermoplastic cellulose derivative. CELLUN made from renewable biopolymers enables the replacement of glass or carbon fibers in the production of industrial molded parts.

Heidelberg University is to acquire a research building to develop innovative engineering science strategies and technologies on the basis of life-inspired molecular systems. The German Science and Humanities Council has now expressed its backing for the idea with an outstanding rating. This recommendation is the crucial precondition for a new building on the university campus Im Neuenheimer Feld.

The Phytopharmaceuticals and Valuable Plant Ingredients initiative aims to further develop phytopharmaceuticals and valuable plant ingredients in Baden-Württemberg.

Tablet-based diagnostics - 12/04/2023

TuCAN - innovative diagnostic procedure for neuropsychiatric disorders

Neuropsychiatric disorders are often diagnosed late and have a negative impact on quality of life. Diagnosing the disease at an early stage is vital to be able to help those affected by offering them treatment adapted to their specific requirements. This is what the TuCAN project in Tübingen aims to achieve through the early and differential diagnosis of neuropsychiatric disorders.

A key enzyme in sugar metabolism is inactivated particularly easily and efficiently by oxidative stress. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now shown that with this oxidation, cells switch to an alternative sugar breakdown pathway and can thus escape oxidative stress. Cancer cells in particular benefit from this mechanism, which can also protect them from therapy-related damage.

City of the future - 04/04/2023

FamoS: climate protection on facades

Resource-efficient water management, photovoltaic modules and innovative facade greening - FamoS is all that. By combining proven elements, the ‘facade module with synergy’ makes a valuable contribution to combatting climate change and boosting climate resilience in cities.

Press release - 31/03/2023

Simulation of Miscanthus- and Sorghum-based resilient value chains in the Danube Region

Can the value chains in the Danube macro-region be more sustainable and resilient against disruptions such as pandemics? How modelling could help to simulate the economic viability of developing Miscanthus and Sorghum based value chains in that region?

Composite materials provide stability in aircraft parts, sports equipment, and everyday household items. However, most of these materials have a poor carbon footprint and are not naturally degradable. A more sustainable alternative has been developed by a team from the University of Stuttgart. This completely bio-based composite material is made of flax fibers and the biopolymer chitosan.

Inovedis GmbH’s innovative implant - 28/03/2023

Next-generation minimally invasive shoulder surgery

The treatment of shoulder injuries such as rotator cuff tears is one of the most common orthopaedic interventions. It is therefore quite surprising that the surgical procedure has not changed much for decades - although it is relatively complicated. The start-up Inovedis has now developed a completely new surgical technique based on an implant that can be performed simply, safely, quickly and cost-effectively with minimal stress for patients.

Sustainable construction - 28/03/2023

Digital manufacturing processes enable buildings to be constructed with flax and willow

A switch to sustainable and circular construction concepts is needed to significantly reduce greenhouse gas emissions in the construction sector. At the German National Garden Show (Bundesgartenschau) in Mannheim, FibR GmbH, together with researchers from the Karlsruhe Institute of Technology, will be showcasing two innovative buildings made from flax and willow, renewable raw materials that exemplify possible building concepts of the future.

Effective drugs against viral diseases like COVID-19 are urgently needed now and in the future. The emergence of viral mutants and yet unknown viruses could push vaccines to their limits. The DZIF scientist and bioinformatician Andreas Dräger from the University of Tübingen is working on a computer-based method that can help to accelerate the time-consuming identification and development of antiviral agents. Using a novel analysis technique that…

Development of anti-tumour agents - 20/03/2023

Targeting the protective shield of cancers

Cancer cells have different mechanisms to help them escape destruction by the immune system. Solid tumours, for example, are often surrounded by a protective layer of lactate, which has a strong immunosuppressive effect. WMT AG from Heidelberg is developing small drug molecules that reduce lactate production and thus make cancer cells vulnerable to immune system attacks.

Residual materials with potential - 16/03/2023

PeePower™ – energy from urine

The objective of the PeePower™ BUGA 2023 collaborative research project is to produce green hydrogen and platform chemicals from wastewater. This fits in nicely with BUGA 2023’s (German National Garden Show) four major themes, namely, climate, energy, environment and food security.

How can camera images be used during minimally invasive surgeries to assess whether the operated organ is sufficiently perfused with blood? Scientists from the German Cancer Research Center (DKFZ) and the Städtisches Klinikum Karlsruhe have now succeeded in automatic monitoring of ischemia during a kidney surgery using only the optical properties of the tissue and not relying on injection of contrast agent.

A novel, both environmentally friendly and cost-saving process for the production of carbon fibers from lignin has been developed at DITF. It is characterized by high energy-saving potential. The avoidance of solvents and the use of natural raw materials make the process environmentally friendly.

Expert interview - 08/03/2023

How do new active substances from university research reach patients?

Access to capital remains one of the biggest challenges in the life sciences sector. Over the last two years, the Baden-Württemberg Center for Academic Drug Discovery (BWCAD2) has successfully implemented a model of cooperation between academic drug research and industry for the development and validation of therapeutic concepts. Dr. Barbara Jonischkeit spoke with the initiator and leading figure behind the BWCAD2 project, Prof. Dr. Stefan Laufer

In February, the Estonian-based startup New Standard Oil successfully commissioned their first industrial-scale prototype for drying and torrefaction of biogenic feedstock operating with superheated steam at atmospheric pressure.

Bacteria of the species Pseudomonas aeruginosa are antibiotic-resistant hospital germs that can enter blood, lungs and other tissues through wounds and cause life-threatening infections. In a joint project, researchers from the Universities of Freiburg and Strasbourg in France have discovered a mechanism that likely contributes to the severity of P. aeruginosa infections.

Researchers at the University of Freiburg have examined how mulching at different times affects insect flower-visitors and larvae.

Immune complexes in COVID-19 - 01/03/2023

Vicious circle of hyperinflammation

Whether a person experiences only a mild malaise or a critical course of disease after a coronavirus infection apparently depends on the antigen-antibody complexes that form in our body. The discovery of these immune complexes set a group of researchers, headed up by Prof. Dr. Hartmut Hengel from the Freiburg University Medical Centre, on the trail of a vicious circle of constantly escalating inflammation.